Clinical Relevance of Sinus Rhythm Mapping to Quantify Electropathology Related to Atrial Fibrillation

Mathijs S. van Schie; Natasja M.S. de Groot

doi:10.15420/AER.2022.03

Clinical Relevance of Sinus Rhythm Mapping to Quantify Electropathology Related to Atrial Fibrillation

Mathijs S. van Schie
, Natasja M.S. de Groot^*

^*Corresponding author for this work

Cardiology

Research output: Contribution to journal › Review article › Academic › peer-review

7 Citations (Scopus)

38 Downloads (Pure)

Abstract

Progression of AF is accompanied by structural and electrical remodelling, resulting in complex electrical conduction disorders. This is defined as electropathology and it increases with the progression of AF. The severity of electropathology, thus, defines the stage of AF and is a major determinant of effectiveness of AF therapy. As specific features of AF-related electropathology are still unknown, it is essential to first quantify the electrophysiological properties of atrial tissue and then to examine the inter- and intra-individual variation during normal sinus rhythm. Comparison of these parameters between patients with and without a history of AF unravels quantified electrophysiological features that are specific to AF patients. This can help to identify patients at risk for early onset or progression of AF. This review summarises current knowledge on quantified features of atrial electrophysiological properties during sinus rhythm and discusses its relevance in identifying AF-related electropathology.

Original language	English
Article number	e11
Journal	Arrhythmia and Electrophysiology Review
Volume	11
DOIs	https://doi.org/10.15420/AER.2022.03
Publication status	Published - 2022

Bibliographical note

Funding Information:
Disclosures: The authors have no conflicts of interest to declare. Funding: NMSdG is supported by funding grants from CVON-AFFIP (grant number 914728), NWO-Vidi (grant number 91717339), Biosense Webster USA (ICD 783454) and Medical Delta. Received: 16 January 2022 Accepted: 25 May 2022 Citation: Arrhythmia & Electrophysiology Review 2022;11:e11. DOI: https://doi.org/10.15420/aer.2022.03 Correspondence: Natasja MS de Groot, Unit Translational Electrophysiology, Department of Cardiology, Erasmus Medical Center, Dr Molewaterplein 40, 3015GD Rotterdam, the Netherlands. E: [email protected] Open Access: This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.

Publisher Copyright:
© 2022 Radcliffe Group Ltd. All rights reserved.

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aer-11-e11Final published version, 2.6 MBLicence: CC BY-NC

Cite this

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title = "Clinical Relevance of Sinus Rhythm Mapping to Quantify Electropathology Related to Atrial Fibrillation",

abstract = "Progression of AF is accompanied by structural and electrical remodelling, resulting in complex electrical conduction disorders. This is defined as electropathology and it increases with the progression of AF. The severity of electropathology, thus, defines the stage of AF and is a major determinant of effectiveness of AF therapy. As specific features of AF-related electropathology are still unknown, it is essential to first quantify the electrophysiological properties of atrial tissue and then to examine the inter- and intra-individual variation during normal sinus rhythm. Comparison of these parameters between patients with and without a history of AF unravels quantified electrophysiological features that are specific to AF patients. This can help to identify patients at risk for early onset or progression of AF. This review summarises current knowledge on quantified features of atrial electrophysiological properties during sinus rhythm and discusses its relevance in identifying AF-related electropathology.",

author = "\{van Schie\}, \{Mathijs S.\} and \{de Groot\}, \{Natasja M.S.\}",

note = "Funding Information: Disclosures: The authors have no conflicts of interest to declare. Funding: NMSdG is supported by funding grants from CVON-AFFIP (grant number 914728), NWO-Vidi (grant number 91717339), Biosense Webster USA (ICD 783454) and Medical Delta. Received: 16 January 2022 Accepted: 25 May 2022 Citation: Arrhythmia \& Electrophysiology Review 2022;11:e11. DOI: https://doi.org/10.15420/aer.2022.03 Correspondence: Natasja MS de Groot, Unit Translational Electrophysiology, Department of Cardiology, Erasmus Medical Center, Dr Molewaterplein 40, 3015GD Rotterdam, the Netherlands. E: [email protected] Open Access: This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly. Publisher Copyright: {\textcopyright} 2022 Radcliffe Group Ltd. All rights reserved.",

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doi = "10.15420/AER.2022.03",

language = "English",

volume = "11",

journal = "Arrhythmia and Electrophysiology Review",

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N1 - Funding Information: Disclosures: The authors have no conflicts of interest to declare. Funding: NMSdG is supported by funding grants from CVON-AFFIP (grant number 914728), NWO-Vidi (grant number 91717339), Biosense Webster USA (ICD 783454) and Medical Delta. Received: 16 January 2022 Accepted: 25 May 2022 Citation: Arrhythmia & Electrophysiology Review 2022;11:e11. DOI: https://doi.org/10.15420/aer.2022.03 Correspondence: Natasja MS de Groot, Unit Translational Electrophysiology, Department of Cardiology, Erasmus Medical Center, Dr Molewaterplein 40, 3015GD Rotterdam, the Netherlands. E: [email protected] Open Access: This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly. Publisher Copyright: © 2022 Radcliffe Group Ltd. All rights reserved.

PY - 2022

Y1 - 2022

N2 - Progression of AF is accompanied by structural and electrical remodelling, resulting in complex electrical conduction disorders. This is defined as electropathology and it increases with the progression of AF. The severity of electropathology, thus, defines the stage of AF and is a major determinant of effectiveness of AF therapy. As specific features of AF-related electropathology are still unknown, it is essential to first quantify the electrophysiological properties of atrial tissue and then to examine the inter- and intra-individual variation during normal sinus rhythm. Comparison of these parameters between patients with and without a history of AF unravels quantified electrophysiological features that are specific to AF patients. This can help to identify patients at risk for early onset or progression of AF. This review summarises current knowledge on quantified features of atrial electrophysiological properties during sinus rhythm and discusses its relevance in identifying AF-related electropathology.

AB - Progression of AF is accompanied by structural and electrical remodelling, resulting in complex electrical conduction disorders. This is defined as electropathology and it increases with the progression of AF. The severity of electropathology, thus, defines the stage of AF and is a major determinant of effectiveness of AF therapy. As specific features of AF-related electropathology are still unknown, it is essential to first quantify the electrophysiological properties of atrial tissue and then to examine the inter- and intra-individual variation during normal sinus rhythm. Comparison of these parameters between patients with and without a history of AF unravels quantified electrophysiological features that are specific to AF patients. This can help to identify patients at risk for early onset or progression of AF. This review summarises current knowledge on quantified features of atrial electrophysiological properties during sinus rhythm and discusses its relevance in identifying AF-related electropathology.

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Clinical Relevance of Sinus Rhythm Mapping to Quantify Electropathology Related to Atrial Fibrillation

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