Clinical results with the Resolute zotarolimus-eluting stent in total coronary occlusions

H Kelbaek, L Holmvang, G Richardt, FR Eberli, P Stella, PE Buszman, FJ Neumann, PWJC (Patrick) Serruys, S Windecker, P Widimsky, JA Belardi, S Silber

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Abstract

Aims: We conducted a pooled post hoc analysis (RESOLUTE All Corners and RESOLUTE International) of patients who had the Resolute (R) zotarolimus-eluting stent (R-ZES) implanted in revascularised total occlusions (TO) compared with patients treated with R-ZES for non-occluded lesions. Methods and results: Patients were divided into three groups: chronic TO (CTO; n=256), non-chronic TO (n=292), and no occlusion (n=2,941). Clinical and safety outcomes assessed through two years included target lesion failure (TLF: cardiac death, target vessel myocardial infarction, and clinically driven target lesion revascularisation) and Academic Research Consortium definite or probable stent thrombosis. The rate of TLF at two years was not significantly different among patients in the CTO (9.1%), TO (9.8%), and no occlusion (10.4%) groups (log-rank p=0.800); neither were the components of TLF. Definite or probable stent thrombosis occurred more frequently in the TO group (2.8% vs. 1.2% in the CTO and 1.1% in the group with no occlusion, p=0.027). There were 10 late and six very late stent thrombosis events. Conclusions: Apart from a higher rate of stent thrombosis in patients with TO, patients with totally occluded coronary arteries who receive revascularisation with an R-ZES have clinical outcomes comparable to those who receive a similar stent in non-occluded lesions.
Original languageUndefined/Unknown
Pages (from-to)650-657
Number of pages8
JournalEuroIntervention
Volume11
Issue number6
Publication statusPublished - 2015

Research programs

  • EMC COEUR-09

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