Clinical translation of multipotent mesenchymal stromal cells in transplantation

Daniëlle G. Leuning, Marlies E.J. Reinders, Johannes W. de Fijter, Ton J. Rabelink*

*Corresponding author for this work

Research output: Contribution to journalReview articlePopular

7 Citations (Scopus)

Abstract

The prevalence of chronic kidney disease and end-stage renal disease is increasing each year and currently the best therapeutic option for end-stage renal disease patients is kidney transplantation. However, although short-term graft outcomes after transplantation have improved substantially as a result of new and more potent immunosuppressive drugs, the long-term survival has hardly changed. This most likely is caused by a combination of nonimmunologic side effects and sustained alloreactivity to the graft resulting in fibrosis. In addition, current immunosuppressive drugs have side effects, including nephrotoxicity, infections, and malignancies that compromise long-term outcomes. Consequently, there is a strong interest in immunosuppressive therapies that maintain efficacy, while reducing side effects. Because mesenchymal stromal cells have potent anti-inflammatory and antifibrotic properties, these cells are of particular interest as new candidates in transplant recipients. Mesenchymal stromal cells might play roles in the treatment of allograft rejection and fibrosis and in calcineurin minimization and induction protocols. In the present review we discuss both preclinical as well as clinical evidence of their therapeutic potential in kidney transplantation. In addition, challenges and obstacles for clinical translation are discussed.

Original languageEnglish
Pages (from-to)351-364
Number of pages14
JournalSeminars in Nephrology
Volume34
Issue number4
DOIs
Publication statusPublished - 1 Jul 2014
Externally publishedYes

Bibliographical note

Funding Information:
Financial support: Supported by the European Community’s Seventh Framework Program (FP7/2007-2013) under grant agreement number 305436.

Publisher Copyright:
© 2014 Elsevier Inc.

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