Clinicopathologic Spectrum of Secondary Solid Tumors of the Prostate of Nonurothelial Origin: Multi-institutional Evaluation of 85 Cases

Andres M. Acosta*, Jennifer B. Gordetsky, Katrina Collins, Adeboye O. Osunkoya, Ankur R. Sangoi, Hiroshi Miyamoto, Chia Sui Kao, Kiril Trpkov, Geert J.L.H. Van Leenders, Sara E. Wobker, Fiona Maclean, Priti Lal, Reba E. Daniel, Fadi Brimo, Matthew Wasco, Michelle S. Hirsch, Nicholas Baniak, Julio A. Diaz-Perez, Kristine M. Cornejo, Bonnie ChoyRohit Mehra, Sean R. Williamson, Jonathan I. Epstein, Andres Matoso

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Secondary involvement of the prostate by urothelial or hematolymphoid neoplasms is relatively common and well-described. In contrast, less is known about the clinicopathologic spectrum of secondary solid tumors of the prostate of nonurothelial origin. This study evaluated a series of secondary nonurothelial solid tumors of the prostate diagnosed at 21 institutions. Eighty-five patients with a median age at diagnosis of 64 years were included. Sixty-two patients had clinically manifest disease (62/85, 73%), 10 were diagnosed incidentally (10/85, 12%), and 13 (13/85, 15%) had no detailed clinical data available about symptomatology at presentation. Among patients with clinically manifest disease, the most common symptoms and signs were lower urinary tract symptoms (either obstructive of irritative; 36/62, 58%), abdominal or pelvic pain or discomfort (16/62, 26%), and hematuria (12/62, 19%). Metastasis and direct invasion occurred at roughly similar frequencies (47% vs. 42%) in this series, and in 11% of the cases, the mechanism of spread to the prostate was unclear/uncertain. Overall, among tumors with confirmed sites of origin, the most common primary sites were gastrointestinal tract (53/85, 62%), lung (9/85, 11%), skin (6/85, 7%), and testis (4/85, 5%). Among metastases, the most common tumor types were lung carcinomas (9/40, 23%), colorectal adenocarcinomas (7/40, 18%), melanoma (6/40, 15%), and germ cell tumors (6/40, 15%). This study demonstrated that secondary involvement of the prostate by solid tumors of nonurothelial origin is commonly symptomatic and that the most frequent sites of origin are the gastrointestinal tract, lung, skin, and testis. These findings are worth considering when lesions with unusual cytomorphology and/or architecture are encountered in prostate specimens.

Original languageEnglish
Pages (from-to)1269-1276
Number of pages8
JournalAmerican Journal of Surgical Pathology
Issue number9
Publication statusPublished - Sept 2022

Bibliographical note

Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.


Dive into the research topics of 'Clinicopathologic Spectrum of Secondary Solid Tumors of the Prostate of Nonurothelial Origin: Multi-institutional Evaluation of 85 Cases'. Together they form a unique fingerprint.

Cite this