Clozapine-Associated Pulmonary Embolism: Continuation of Clozapine Therapy With Concurrent Anticoagulation

M. R. Jahangir; C. Heerema; J. Biedermann; S. Dieleman; N. H. Grootendorst-van Mil

doi:10.1155/crps/6686502

Clozapine-Associated Pulmonary Embolism: Continuation of Clozapine Therapy With Concurrent Anticoagulation

M. R. Jahangir
, C. Heerema
, J. Biedermann
, S. Dieleman
, N. H. Grootendorst-van Mil^*

^*Corresponding author for this work

Psychiatry

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Clozapine, a gold standard for treatment-resistant schizophrenia, is associated with a range of adverse effects, including the rare but serious risk of pulmonary embolism (PE). The management of such complications, particularly in the absence of clear guidelines for preventive anticoagulation, poses significant challenges. We present a case of a male (in his late 30s) with schizophrenia who developed recurrent thromboembolic events during clozapine therapy. Despite the occurrence of a second PE, clozapine therapy was continued successfully with concurrent anticoagulation. This case highlights the need for individualized treatment strategies and underscores the critical gap in evidence regarding preventive anticoagulation in patients with clozapine.

Original language	English
Article number	6686502
Journal	Case Reports in Psychiatry
Volume	2026
Issue number	1
DOIs	https://doi.org/10.1155/crps/6686502
Publication status	E-pub ahead of print - 6 Jan 2026

Bibliographical note

Publisher Copyright:
Copyright © 2026 M. R. Jahangir et al. Case Reports in Psychiatry published by John Wiley & Sons Ltd.

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Case Reports in Psychiatry - 2026 - Jahangir - Clozapine‐Associated Pulmonary Embolism Continuation of Clozapine TherapyFinal published version, 338 KBLicence: CC BY

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AU - Dieleman, S.

AU - Grootendorst-van Mil, N. H.

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AB - Clozapine, a gold standard for treatment-resistant schizophrenia, is associated with a range of adverse effects, including the rare but serious risk of pulmonary embolism (PE). The management of such complications, particularly in the absence of clear guidelines for preventive anticoagulation, poses significant challenges. We present a case of a male (in his late 30s) with schizophrenia who developed recurrent thromboembolic events during clozapine therapy. Despite the occurrence of a second PE, clozapine therapy was continued successfully with concurrent anticoagulation. This case highlights the need for individualized treatment strategies and underscores the critical gap in evidence regarding preventive anticoagulation in patients with clozapine.

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Clozapine-Associated Pulmonary Embolism: Continuation of Clozapine Therapy With Concurrent Anticoagulation

Abstract

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