Clusters of risk factors in metabolic syndrome and their influence on central blood pressure in a global study

Agne Laucyte-Cibulskiene*, Chen Huan Chen, John Cockroft, Pedro G. Cunha, Maryam Kavousi, Aleksandras Laucevicius, Maria Lorenza Muiesan, Ernst R. Rietzschel, Ligita Ryliskyte, Irina D. Strazhesko, Charalambos Vlachopoulos, Jorge Cotter, Ekatherina N. Dudinskaya, Nichola Gale, Fariba Ahmadizar, Francesco U.S. Mattace-Raso, Maggie Munnery, Pedro Oliveira, Anna Paini, Massimo SalvettiOlga N. Tkacheva, Edward G. Lakatta, Peter M. Nilsson, Angelo Scuteri

*Corresponding author for this work

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The effect of metabolic syndrome (MetS) and clusters of its components on central blood pressure (CBP) has not been well characterized. We aimed to describe the effect of MetS and clusters of its components on CBP in a large population and to identify whether this effect differs in men and women. We studied 15,609 volunteers (43% women) from 10 cohorts worldwide who participated in the Metabolic syndrome and Artery REsearch Consortium. MetS was defined according to the NCEP-ATP III criteria (GHTBW, glucose, high-density lipoprotein cholesterol, triglyceride, blood pressure, waist circumference). CBP was measured noninvasively and acquired from pulse wave analysis by applanation tonometry. MetS was associated with a 50% greater odds of having higher CSBP. After controlling for age, male sex, non HDL cholesterol, diabetes mellitus, and mean arterial pressure, only specific clusters of MetS components were associated with a higher CSBP; and some of them were significant in women but not in men. We identified “risky clusters” of MetS variables associated with high CSBP. Future studies are needed to confirm they identify subjects at high risk of accelerated arterial aging and, thus, need more intensive clinical management.

Original languageEnglish
Article number14409
JournalScientific Reports
Issue number1
Publication statusPublished - 24 Aug 2022

Bibliographical note

Funding Information:
Open access funding provided by Lund University. The Asklepios Study is supported by the Fund for Scientific Research—Flanders (FWO research grants G042703 and G083810N). The Rotterdam Study is supported by the Erasmus Medical Center and Erasmus University Rotterdam; the Netherlands Organization for Scientific Research; the Netherlands Organization for Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); the Netherlands Heart Foundation; the Ministry of Education, Culture and Science; the Ministry of Health Welfare and Sports; the European Commission; and the Municipality of Rotterdam. The SardiNIA team was supported by Contract NO1-AG-1-2109 from the NIA. This research was partly supported by the Intramural Research Program of the NIH, National Institute on Aging (USA). The LitHiR program was reimbursed from the Statutory Health Insurance Fund (Lithuania). The Malmö Diet and Cancer Study (MDCS) has been supported by a Lund University Infrastructure grant “Malmö population-based cohorts” (STYR 2019/2046). The SMART study was funded initially by Takeda. The Vobarno Study is supported by grants from the European Community Network of Excellence (InGenious HyperCare, 2006 to 2010); Italian University and Research Ministry, Regione Lombardia, and Fondazione della Comunità Bresciana Onlus.

Publisher Copyright:
© 2022, The Author(s).


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