CMAP scan discontinuities: Automated detection and relation to motor unit loss

Boudewijn Sleutjes, Inger Montfoort, EM Maathuis, J. Drenthen, Pieter van Doorn, GH Visser, JH Blok

Research output: Contribution to journalArticleAcademic

23 Citations (Scopus)

Abstract

Objective: To evaluate an automated method that extracts motor unit (MU) information from the CMAP scan, a high-detail stimulus-response curve recorded with surface EMG. Discontinuities in the CMAP scan are hypothesized to result from MU loss and reinnervation. Methods: We introduce the parameter D50 to quantify CMAP scan discontinuities. D50 was compared with a previously developed manual score in 253 CMAP scans and with a simultaneously obtained motor unit number estimate (MUNE) in 173 CMAP scans. The effect of MU loss on D50 was determined with a simulation model. Results: We found a high agreement (sensitivity = 86.8%, specificity = 96.6%) between D50 and the manual score. D50 and MUNE were significantly correlated below 80 MUs (r = 0.65, n = 68, p < 0.001), but not when MUNE was larger than 120 MUs (r = 0.23, n = 59, p = 0.08). Conclusions: Discontinuities in the CMAP scan as expressed by a decreased D50 are related to significant MU loss. The determination of D50 is objective, quantitative, and less time-consuming than both manual scoring and many existing MUNE methods. Significance: D50 is potentially useful to monitor neurogenic disorders and moderate to severe MU loss. (C) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)388-395
Number of pages8
JournalClinical Neurophysiology
Volume125
Issue number2
DOIs
Publication statusPublished - 2014

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