Cognitive dysfunction in patients with type 2 diabetes

Yael D. Reijmer, Esther van den Berg, Carla Ruis, L. Jaap Kappelle, Geert Jan Biessels*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

186 Citations (Scopus)

Abstract

People with diabetes mellitus are at increased risk of cognitive dysfunction and dementia. This review explores the nature and severity of cognitive changes in patients with type 2 diabetes. Possible risk factors such as hypo- and hyperglycemia, vascular risk factors, micro- and macrovascular complications, depression and genetic factors will be examined, as well as findings from brain imaging and autopsy studies. We will show that type 2 diabetes is associated with modest cognitive decrements in non-demented patients that evolve only slowly over time, but also with an increased risk of more severe cognitive deficits and dementia. There is a dissociation between these two 'types' of cognitive dysfunction with regard to affected age groups and course of development. Therefore, we hypothesize that the mild and severe cognitive deficits observed in patients with type 2 diabetes reflect separate processes, possibly with different risk factors and aetiologies. Copyright (C) 2010 John Wiley & Sons, Ltd.

Original languageEnglish
Pages (from-to)507-519
Number of pages13
JournalDiabetes-Metabolism Research and Reviews
Volume26
Issue number7
Early online date26 Aug 2010
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

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