TY - JOUR
T1 - Cognitive function and vitamin B12 and D among community-dwelling elders
T2 - A cross-sectional study
AU - Vinueza Veloz, Andrés Fernando
AU - Carpio Arias, Tannia Valeria
AU - Vargas Mejía, Jénifer Sthefania
AU - Tapia Veloz, Estephany Carolina
AU - Piedra Andrade, Jefferson Santiago
AU - Nicolalde Cifuentes, Tomás Marcelo
AU - Heredia Aguirre, Susana Isabel
AU - Vinueza Veloz, María Fernanda
N1 - Funding Information:
We would like to thank to Arq. Carlos Martín Román, Prof.dr. Chris de Zeeuw, Dr. María Paulina Robalino Valdivieso and The Research Institute (IDI) from ESPOCH for their academic support. We would also like to thank to the coordination team of the SABE study as well as their participants.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/8/1
Y1 - 2022/8/1
N2 - Background & aims: Little is know on the association between mild or sub-clinical vitamin B12 or D deficiencies and cognitive decline. The objective of the present work was to evaluate the association between vitamin B12 and D levels, and cognitive function in community-dwelling elders. Methods: Cross-sectional study that included data from elders who participated in the SABE study, a population-based study that was carried out in Ecuador. Participants of SABE were selected by probabilistic sampling from the whole country. Vitamin B12 and D were measured in blood and cognitive status was assessed using an abbreviated version of the minimental state examination (MMSE). Results: The sample included 1733 elders from whom 936 (54.01%) were female. Independently from sex, age, years of education, ethnicity, socioeconomic status and geographical zone of residence, we found that vitamin B12 levels were associated to MMSE scores and that this relationship changed depending on age. In this way, we observed that from 75 years of age, drop of cognitive function was particularly steep in individuals with low levels of vitamin B12. We did not find evidence to support an association between vitamin D levels and cognitive function. Conclusions: Low levels of vitamin B12 but not of vitamin D are associated with low cognitive functioning in a sample of community-dwelling elders.
AB - Background & aims: Little is know on the association between mild or sub-clinical vitamin B12 or D deficiencies and cognitive decline. The objective of the present work was to evaluate the association between vitamin B12 and D levels, and cognitive function in community-dwelling elders. Methods: Cross-sectional study that included data from elders who participated in the SABE study, a population-based study that was carried out in Ecuador. Participants of SABE were selected by probabilistic sampling from the whole country. Vitamin B12 and D were measured in blood and cognitive status was assessed using an abbreviated version of the minimental state examination (MMSE). Results: The sample included 1733 elders from whom 936 (54.01%) were female. Independently from sex, age, years of education, ethnicity, socioeconomic status and geographical zone of residence, we found that vitamin B12 levels were associated to MMSE scores and that this relationship changed depending on age. In this way, we observed that from 75 years of age, drop of cognitive function was particularly steep in individuals with low levels of vitamin B12. We did not find evidence to support an association between vitamin D levels and cognitive function. Conclusions: Low levels of vitamin B12 but not of vitamin D are associated with low cognitive functioning in a sample of community-dwelling elders.
UR - http://www.scopus.com/inward/record.url?scp=85132343765&partnerID=8YFLogxK
U2 - 10.1016/j.clnesp.2022.05.004
DO - 10.1016/j.clnesp.2022.05.004
M3 - Article
C2 - 35871935
AN - SCOPUS:85132343765
SN - 2405-4577
VL - 50
SP - 270
EP - 276
JO - Clinical Nutrition ESPEN
JF - Clinical Nutrition ESPEN
ER -
