Cognitive function and vitamin B12 and D among community-dwelling elders: A cross-sectional study

Andrés Fernando Vinueza Veloz; Tannia Valeria Carpio Arias; Jénifer Sthefania Vargas Mejía; Estephany Carolina Tapia Veloz; Jefferson Santiago Piedra Andrade; Tomás Marcelo Nicolalde Cifuentes; Susana Isabel Heredia Aguirre; María Fernanda Vinueza Veloz

doi:10.1016/j.clnesp.2022.05.004

Cognitive function and vitamin B12 and D among community-dwelling elders: A cross-sectional study

Andrés Fernando Vinueza Veloz
, Tannia Valeria Carpio Arias
, Jénifer Sthefania Vargas Mejía
, Estephany Carolina Tapia Veloz
, Jefferson Santiago Piedra Andrade
, Tomás Marcelo Nicolalde Cifuentes
, Susana Isabel Heredia Aguirre
, María Fernanda Vinueza Veloz^*

^*Corresponding author for this work

Neurosciences

Hospital Clínico Quirúrgico Hermanos Ameijeiras
Escuela Superior Politécnica de Chimborazo
Gamma Salud Hospital
University of Valencia
Hospital Carlos Andrade Marin
University of Oslo

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

95 Downloads (Pure)

Abstract

Background & aims: Little is know on the association between mild or sub-clinical vitamin B12 or D deficiencies and cognitive decline. The objective of the present work was to evaluate the association between vitamin B12 and D levels, and cognitive function in community-dwelling elders. Methods: Cross-sectional study that included data from elders who participated in the SABE study, a population-based study that was carried out in Ecuador. Participants of SABE were selected by probabilistic sampling from the whole country. Vitamin B12 and D were measured in blood and cognitive status was assessed using an abbreviated version of the minimental state examination (MMSE). Results: The sample included 1733 elders from whom 936 (54.01%) were female. Independently from sex, age, years of education, ethnicity, socioeconomic status and geographical zone of residence, we found that vitamin B12 levels were associated to MMSE scores and that this relationship changed depending on age. In this way, we observed that from 75 years of age, drop of cognitive function was particularly steep in individuals with low levels of vitamin B12. We did not find evidence to support an association between vitamin D levels and cognitive function. Conclusions: Low levels of vitamin B12 but not of vitamin D are associated with low cognitive functioning in a sample of community-dwelling elders.

Original language	English
Pages (from-to)	270-276
Number of pages	7
Journal	Clinical Nutrition ESPEN
Volume	50
DOIs	https://doi.org/10.1016/j.clnesp.2022.05.004
Publication status	Published - 1 Aug 2022

Bibliographical note

Funding Information:
We would like to thank to Arq. Carlos Martín Román, Prof.dr. Chris de Zeeuw, Dr. María Paulina Robalino Valdivieso and The Research Institute (IDI) from ESPOCH for their academic support. We would also like to thank to the coordination team of the SABE study as well as their participants.

Publisher Copyright:
© 2022 The Author(s)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Cite this

Vinueza Veloz, A. F., Carpio Arias, T. V., Vargas Mejía, J. S., Tapia Veloz, E. C., Piedra Andrade, J. S., Nicolalde Cifuentes, T. M., Heredia Aguirre, S. I., & Vinueza Veloz, M. F. (2022). Cognitive function and vitamin B12 and D among community-dwelling elders: A cross-sectional study. Clinical Nutrition ESPEN, 50, 270-276. https://doi.org/10.1016/j.clnesp.2022.05.004

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title = "Cognitive function and vitamin B12 and D among community-dwelling elders: A cross-sectional study",

abstract = "Background \& aims: Little is know on the association between mild or sub-clinical vitamin B12 or D deficiencies and cognitive decline. The objective of the present work was to evaluate the association between vitamin B12 and D levels, and cognitive function in community-dwelling elders. Methods: Cross-sectional study that included data from elders who participated in the SABE study, a population-based study that was carried out in Ecuador. Participants of SABE were selected by probabilistic sampling from the whole country. Vitamin B12 and D were measured in blood and cognitive status was assessed using an abbreviated version of the minimental state examination (MMSE). Results: The sample included 1733 elders from whom 936 (54.01\%) were female. Independently from sex, age, years of education, ethnicity, socioeconomic status and geographical zone of residence, we found that vitamin B12 levels were associated to MMSE scores and that this relationship changed depending on age. In this way, we observed that from 75 years of age, drop of cognitive function was particularly steep in individuals with low levels of vitamin B12. We did not find evidence to support an association between vitamin D levels and cognitive function. Conclusions: Low levels of vitamin B12 but not of vitamin D are associated with low cognitive functioning in a sample of community-dwelling elders.",

author = "\{Vinueza Veloz\}, \{Andr{\'e}s Fernando\} and \{Carpio Arias\}, \{Tannia Valeria\} and \{Vargas Mej{\'i}a\}, \{J{\'e}nifer Sthefania\} and \{Tapia Veloz\}, \{Estephany Carolina\} and \{Piedra Andrade\}, \{Jefferson Santiago\} and \{Nicolalde Cifuentes\}, \{Tom{\'a}s Marcelo\} and \{Heredia Aguirre\}, \{Susana Isabel\} and \{Vinueza Veloz\}, \{Mar{\'i}a Fernanda\}",

note = "Funding Information: We would like to thank to Arq. Carlos Mart{\'i}n Rom{\'a}n, Prof.dr. Chris de Zeeuw, Dr. Mar{\'i}a Paulina Robalino Valdivieso and The Research Institute (IDI) from ESPOCH for their academic support. We would also like to thank to the coordination team of the SABE study as well as their participants. Publisher Copyright: {\textcopyright} 2022 The Author(s)",

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month = aug,

day = "1",

doi = "10.1016/j.clnesp.2022.05.004",

language = "English",

volume = "50",

pages = "270--276",

journal = "Clinical Nutrition ESPEN",

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TY - JOUR

T1 - Cognitive function and vitamin B12 and D among community-dwelling elders

T2 - A cross-sectional study

AU - Vinueza Veloz, Andrés Fernando

AU - Carpio Arias, Tannia Valeria

AU - Vargas Mejía, Jénifer Sthefania

AU - Tapia Veloz, Estephany Carolina

AU - Piedra Andrade, Jefferson Santiago

AU - Nicolalde Cifuentes, Tomás Marcelo

AU - Heredia Aguirre, Susana Isabel

AU - Vinueza Veloz, María Fernanda

N1 - Funding Information: We would like to thank to Arq. Carlos Martín Román, Prof.dr. Chris de Zeeuw, Dr. María Paulina Robalino Valdivieso and The Research Institute (IDI) from ESPOCH for their academic support. We would also like to thank to the coordination team of the SABE study as well as their participants. Publisher Copyright: © 2022 The Author(s)

PY - 2022/8/1

Y1 - 2022/8/1

N2 - Background & aims: Little is know on the association between mild or sub-clinical vitamin B12 or D deficiencies and cognitive decline. The objective of the present work was to evaluate the association between vitamin B12 and D levels, and cognitive function in community-dwelling elders. Methods: Cross-sectional study that included data from elders who participated in the SABE study, a population-based study that was carried out in Ecuador. Participants of SABE were selected by probabilistic sampling from the whole country. Vitamin B12 and D were measured in blood and cognitive status was assessed using an abbreviated version of the minimental state examination (MMSE). Results: The sample included 1733 elders from whom 936 (54.01%) were female. Independently from sex, age, years of education, ethnicity, socioeconomic status and geographical zone of residence, we found that vitamin B12 levels were associated to MMSE scores and that this relationship changed depending on age. In this way, we observed that from 75 years of age, drop of cognitive function was particularly steep in individuals with low levels of vitamin B12. We did not find evidence to support an association between vitamin D levels and cognitive function. Conclusions: Low levels of vitamin B12 but not of vitamin D are associated with low cognitive functioning in a sample of community-dwelling elders.

AB - Background & aims: Little is know on the association between mild or sub-clinical vitamin B12 or D deficiencies and cognitive decline. The objective of the present work was to evaluate the association between vitamin B12 and D levels, and cognitive function in community-dwelling elders. Methods: Cross-sectional study that included data from elders who participated in the SABE study, a population-based study that was carried out in Ecuador. Participants of SABE were selected by probabilistic sampling from the whole country. Vitamin B12 and D were measured in blood and cognitive status was assessed using an abbreviated version of the minimental state examination (MMSE). Results: The sample included 1733 elders from whom 936 (54.01%) were female. Independently from sex, age, years of education, ethnicity, socioeconomic status and geographical zone of residence, we found that vitamin B12 levels were associated to MMSE scores and that this relationship changed depending on age. In this way, we observed that from 75 years of age, drop of cognitive function was particularly steep in individuals with low levels of vitamin B12. We did not find evidence to support an association between vitamin D levels and cognitive function. Conclusions: Low levels of vitamin B12 but not of vitamin D are associated with low cognitive functioning in a sample of community-dwelling elders.

UR - https://www.scopus.com/pages/publications/85132343765

U2 - 10.1016/j.clnesp.2022.05.004

DO - 10.1016/j.clnesp.2022.05.004

M3 - Article

C2 - 35871935

AN - SCOPUS:85132343765

SN - 2405-4577

VL - 50

SP - 270

EP - 276

JO - Clinical Nutrition ESPEN

JF - Clinical Nutrition ESPEN

ER -

Cognitive function and vitamin B12 and D among community-dwelling elders: A cross-sectional study

Abstract

Bibliographical note

UN SDGs

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