Cohort profile update: Tehran cardiometabolic genetic study

Maryam S. Daneshpour*, Mahdi Akbarzadeh, Hossein Lanjanian, Bahar Sedaghati-khayat, Kamran Guity, Sajedeh Masjoudi, Asiyeh Sadat Zahedi, Maryam Moazzam-Jazi, Leila Najd Hassan Bonab, Bita Shalbafan, Sara Asgarian, Goodarz Koli Farhood, Niloofar Javanrooh, Maryam Zarkesh, Parisa Riahi, Mohammad Reza Moghaddas, Parvaneh Arbab Dehkordi, Azar Delbarpour Ahmadi, Firoozeh Hosseini, Sara Jalali FarahaniFarzad Hadaegh, Parvin Mirmiran, Fahimeh Ramezani Tehrani, Arash Ghanbarian, Mohammad Sadegh Fallah Mahboob Pasand, Parisa Amiri, Majid Valizadeh, Farhad Hosseipanah, Maryam Tohidi, Asghar Ghasemi, Azita Zadeh-Vakili, Mohammad Piryaei, Shahram Alamdari, Davood Khalili, Amirabbas Momenan, Maryam Barzin, Sirous Zeinali, Mehdi Hedayati, Fereidoun Azizi*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)


The Tehran cardiometabolic genetic study (TCGS) is a large population-based cohort study that conducts periodic follow-ups. TCGS has created a comprehensive database comprising 20,367 participants born between 1911 and 2015 selected from four main ongoing studies in a family-based longitudinal framework. The study's primary goal is to identify the potential targets for prevention and intervention for non-communicable diseases that may develop in mid-life and late life. TCGS cohort focuses on cardiovascular, endocrine, metabolic abnormalities, cancers, and some inherited diseases. Since 2017, the TCGS cohort has augmented by encoding all health-related complications, including hospitalization outcomes and self-reports according to ICD11 coding, and verifying consanguineous marriage using genetic markers. This research provides an update on the rationale and design of the study, summarizes its findings, and outlines the objectives for precision medicine.

Original languageEnglish
Pages (from-to)699-711
Number of pages13
JournalEuropean Journal of Epidemiology
Issue number6
Publication statusPublished - Jun 2023

Bibliographical note

Funding Information:
This study was funded by the Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences (Tehran, Iran), and the scientific and financial support of the deCODE genetic company (Reykjavik, Iceland). This work was supported by the Ministry of Health and Medical Education (MOHME:700/1736). Shahid Beheshti University for Medical Sciences was granted this project [grant no: 31178]. Iranian molecular medicine network supported the genomic bank.

Publisher Copyright:
© 2023, Springer Nature B.V.


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