Collagen analysis with mass spectrometry

Nick A. van Huizen, Jan N.M. Ijzermans, Peter C. Burgers, Theo M. Luider*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

24 Citations (Scopus)


Mass spectrometry-based techniques can be applied to investigate collagen with respect to identification, quantification, supramolecular organization, and various post-translational modifications. The continuous interest in collagen research has led to a shift from techniques to analyze the physical characteristics of collagen to methods to study collagen abundance and modifications. In this review, we illustrate the potential of mass spectrometry for in-depth analyses of collagen.

Original languageEnglish
Pages (from-to)309-335
Number of pages27
JournalMass Spectrometry Reviews
Issue number4
Publication statusPublished - 1 Jul 2020

Bibliographical note

Funding Information:
The authors gratefully acknowledge the Netherlands Organization for Scientific Research NWO (Domain Applied and Engineering Sciences; Perspectiefprogramma P12-04, project 13541) and the Dutch Biomarker Development Center (BDC; for support of this work.

Publisher Copyright:
© 2019 John Wiley & Sons Ltd.


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