Combined anatomical and clinical factors for the long-term risk stratification of patients undergoing percutaneous coronary intervention: the Logistic Clinical SYNTAX score

V Farooq, Yvonne Vergouwe, L Raber, Pascal Vranckx, H Garcia-Garcia, Roberto Diletti, Arie-Pieter Kappetein, Marie-Angele Morel, T (Ton) de Vries, M Swart, M (Marco) Valgimigli, KD Dawkins, S Windecker, Ewout Steyerberg, PWJC (Patrick) Serruys

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Background The SYNTAX score (SXscore), an anatomical-based scoring tool reflecting the complexity of coronary anatomy, has established itself as an important long-term prognostic factor in patients undergoing percutaneous coronary intervention (PCI). The incorporation of clinical factors may further augment the utility of the SXscore to longer-term risk stratify the individual patient for clinical outcomes. Methods and results Patient-level merged data from >6000 patients in seven contemporary coronary stent trials was used to develop a logistic regression model-the Logistic Clinical SXscore-to predict 1-year risk for all-cause death and major adverse cardiac events (MACE). A core model (composed of the SXscore, age, creatinine clearance, and left ventricular ejection fraction) and an extended model [incorporating the core model and six additional (best performing) clinical variables] were develope Conclusion The Logistic Clinical SXscore substantially enhances the prediction of 1-year mortality after PCI compared with the SXscore, and allows for an accurate personalized assessment of patient risk.
Original languageUndefined/Unknown
Pages (from-to)3098-+
JournalEuropean Heart Journal
Issue number24
Publication statusPublished - 2012

Research programs

  • EMC COEUR-09
  • EMC NIHES-02-65-01

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