Combined optical and acoustical detection of single microbubble dynamics

J Sijl, Rik Vos, T Rozendal, Nico Jong, D Lohse, M Versluis

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33 Citations (Scopus)


A detailed understanding of the response of single microbubbles subjected to ultrasound is fundamental to a full understanding of the contrast-enhancing abilities of microbubbles in medical ultrasound imaging, in targeted molecular imaging with ultrasound, and in ultrasound-mediated drug delivery with microbubbles. Here, single microbubbles are isolated and their ultrasound-induced radial dynamics recorded with an ultra-high-speed camera at up to 25 million frames per second. The sound emission is recorded simultaneously with a calibrated single element transducer. It is shown that the sound emission can be predicted directly from the optically recorded radial dynamics, and vice versa, that the nanometer-scale radial dynamics can be predicted from the acoustic response recorded in the far field. (C) 2011 Acoustical Society of America. [DOI: 10.1121/1.3626155]
Original languageUndefined/Unknown
Pages (from-to)3271-3281
Number of pages11
JournalJournal of the Acoustical Society of America
Issue number5
Publication statusPublished - 2011

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