Abstract
A detailed understanding of the response of single microbubbles subjected to ultrasound is fundamental to a full understanding of the contrast-enhancing abilities of microbubbles in medical ultrasound imaging, in targeted molecular imaging with ultrasound, and in ultrasound-mediated drug delivery with microbubbles. Here, single microbubbles are isolated and their ultrasound-induced radial dynamics recorded with an ultra-high-speed camera at up to 25 million frames per second. The sound emission is recorded simultaneously with a calibrated single element transducer. It is shown that the sound emission can be predicted directly from the optically recorded radial dynamics, and vice versa, that the nanometer-scale radial dynamics can be predicted from the acoustic response recorded in the far field. (C) 2011 Acoustical Society of America. [DOI: 10.1121/1.3626155]
Original language | Undefined/Unknown |
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Pages (from-to) | 3271-3281 |
Number of pages | 11 |
Journal | Journal of the Acoustical Society of America |
Volume | 130 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2011 |