Comparing measurement properties of EQ-5D-Y-3L and EQ-5D-Y-5L in paediatric patients

Titi Sahidah Fitriana*, Fredrick Dermawan Purba, Rina Rahmatika, Riski Muhaimin, Nur Melani Sari, Gouke Bonsel, Elly Stolk, Jan J.V. Busschbach

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
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Background: The adult versions EQ-5D-3L and EQ-5D-5L have been extensive compared. This is not the case for the EQ-5D youth versions. The study aim was to compare the measurement properties and responsiveness of EQ-5D-Y-3L and EQ-5D-Y-5L in paediatric patients. Methods: A sample of patients 8–16 years old with different diseases and a wide range of disease severity was asked to complete EQ-5D-Y-3L, EQ-5D-Y-5L, PedsQL Generic Core Scale, and selected, appropriate disease-specific instruments, three times. EQ-5D-Y-3L and EQ-5D-Y-5L were compared in terms of: feasibility, (re-)distribution properties, discriminatory power, convergent validity, test–retest reliability, and responsiveness. Results: 286 participating patients suffered from one of the following diseases: major beta-thalassemia, haemophilia, acute lymphoblastic leukaemia, acute illness. Missing responses were comparable between versions of the EQ-5D-Y, suggesting comparable feasibility. The number of patients in the best health state (level profile 11111) was equal in both EQ-5D-Y versions. The projection of EQ-5D-Y-3L scores onto EQ-5D-Y-5L for all dimensions showed that the two additional levels in EQ-5D-Y-5L slightly improved the accuracy of patients in reporting their problems, especially if severe. Convergent validity with PedsQL and disease-specific measures showed that the two EQ-5D-Y versions performed about equally. Test–retest reliability (EQ-5D-Y-3L 0.78 vs EQ-5D-Y-5L 0.84), and sensitivity for detecting health changes, were both better in EQ-5D-Y-5L. Conclusions: Extending the number of levels did not give clear superiority to EQ-5D-Y-5L over EQ-5D-Y-3L based on the criteria assessed in this study. However, increasing the number of levels benefitted EQ-5D-Y performance in the measurement of moderate to severe problems and especially in longitudinal study designs.

Original languageEnglish
Article number256
JournalHealth and Quality of Life Outcomes
Issue number1
Publication statusPublished - 15 Nov 2021

Bibliographical note

Funding Information:
Funding for this study was provided by the EuroQol Group grant EQ Project 20180140 and Indonesian Endowment Fund for Education (LPDP). Both grants were unrestricted.

Funding Information:
We would like to thank Mimmi ?str?m for her valuable input, and all those who provided helpful comments at the 2019 EuroQol Plenary Meeting. High appreciation is also given to the 5 participating hospitals (Dharmais Cancer Hospital, Cipto Mangunkusumo Hospital, Islamic Hospital, Hermina Kemayoran Hospital, and Hasan Sadikin Hospital), and to all the hard-working interviewers, especially Putri Andine and Cindi Anggraini.

Publisher Copyright:
© 2021, The Author(s).


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