Comparison of in vivo eccentricity and symmetry indices between metallic stents and bioresorbable vascular scaffolds: Insights from the ABSORB and SPIRIT trials

S Brugaletta, Josep Gomez Lara, Roberto Diletti, V Farooq, Robert Jan van Geuns, B de Bruyne, D Dudek, Hector Garcia Garcia, JA Ormiston, PWJC (Patrick) Serruys

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)


Objective: To compare the geometrical parameters of a bioresorbable vascular scaffold (BVS) with a standard metallic stent. Background: The introduction of polymeric bioresorbable materials in the design of novel coronary scaffolds may affect some geometrical parameters, such as eccentricity and symmetry indices, previously introduced as IVUS criteria for optimal metallic stent deployment. Methods: From ABSORB Cohort A, ABSORB Cohort B, SPIRIT I, and SPIRIT II, all patients implanted with BVS 1.0, BVS 1.1, or XIENCE V, respectively and intravascular ultrasound analyses post-implantation were selected. The eccentricity index was calculated frame by frame and expressed as an average per device (minimum diameter/maximum diameter). The symmetry index of the device was reported as ([maximum diameter - minimum diameter]/maximum diameter).Six months major adverse cardiac events (MACE) were analyzed. Results: A total of 242 patients were selected (BVS 1.0: n = 28, BVS 1.1: n = 94, XIENCE V: n = 120). The BVS exhibited a significantly lower eccentricity index (BVS 1.0: 0.83 +/- 0.09; BVS 1.1: 0.85 +/- 0.08; XIENCE V: 0.90 +/- 0.06; P < 0.01) and a significantly higher symmetry index (BVS 1.0: 0.30 +/- 0.07; BVS 1.1: 0.31 +/- 0.06, XIENCE V 0.26 +/- 0.07; P < 0.01) as compared to the XIENCE V. An inverse correlation was found between the symmetry and eccentricity indices for both (BVS r = -0.69, P < 0.01; XIENCE V r = -0.61, P < 0.01). No differences in MACE were detected between the groups according to their geometrical parameters. Conclusions: The introduction of a new polymeric material in the design of BVS resulted in a lower eccentricity index and a higher symmetry index as compared to metallic stents, without detectable impact in MACE, at 6 months. (C) 2011 Wiley Periodicals, Inc.
Original languageUndefined/Unknown
Pages (from-to)219-228
Number of pages10
JournalCatheterization and Cardiovascular Interventions
Issue number2
Publication statusPublished - 2012

Cite this