Complexity of the Association Between Psoriasis and Comorbidities

Research output: Contribution to journalArticleAcademicpeer-review

100 Citations (Scopus)


Multiple observational studies have recently demonstrated associations between psoriasis and several comorbidities-especially metabolic syndrome and cardiovascular disease, and now osteoporosis. It has been hypothesized that elevated levels of tumor necrosis factor-alpha are a biological explanation for the observed associations. In this commentary, we discuss the complexity of associations between psoriasis and comorbidities, possible residual confounding, the limitations of observational studies in proving causality, absolute versus relative risk differences, and the clinical relevance and possible clinical impact of "upgrading" psoriasis to a systemic disease.
Original languageUndefined/Unknown
Pages (from-to)1601-1603
Number of pages3
JournalJournal of Investigative Dermatology
Issue number7
Publication statusPublished - 2009

Research programs

  • EMC MM-03-61-05-A

Cite this