Complexity of the Association Between Psoriasis and Comorbidities

Tamar Nijsten; Marlies Wakkee

doi:10.1038/jid.2009.55

Complexity of the Association Between Psoriasis and Comorbidities

Dermatology

Research output: Contribution to journal › Article › Academic › peer-review

101 Citations (Scopus)

Abstract

Multiple observational studies have recently demonstrated associations between psoriasis and several comorbidities-especially metabolic syndrome and cardiovascular disease, and now osteoporosis. It has been hypothesized that elevated levels of tumor necrosis factor-alpha are a biological explanation for the observed associations. In this commentary, we discuss the complexity of associations between psoriasis and comorbidities, possible residual confounding, the limitations of observational studies in proving causality, absolute versus relative risk differences, and the clinical relevance and possible clinical impact of "upgrading" psoriasis to a systemic disease.

Original language	Undefined/Unknown
Pages (from-to)	1601-1603
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	129
Issue number	7
DOIs	https://doi.org/10.1038/jid.2009.55
Publication status	Published - 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research programs

EMC MM-03-61-05-A

Access to Document

10.1038/jid.2009.55

http://hdl.handle.net/1765/27056

Cite this

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