Compliance, persistence, costs and quality of life in young patients treated with antipsychotic drugs: results from the COMETA study

PA Cortesi, C Mencacci, F Luigi, E Pirfo, P Berto, MCJM Sturkenboom, FL Lopes, MG Giustra, LG Mantovani, L Scalone

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Abstract

Background: Little data is available on the real-world socio-economic burden and outcomes in schizophrenia. This study aimed to assess persistence, compliance, costs and Health-Related Quality-of-Life (HRQoL) in young patients undergoing antipsychotic treatment according to clinical practice. Methods: A naturalistic, longitudinal, multicentre cohort study was conducted: we involved 637 patients aged 18-40 years, with schizophrenia or schizophreniform disorder diagnosed <= 10 years before, enrolled in 86 Italian Mental Health Centres and followed-up for 1 year. Comparisons were conducted between naive (i.e., patients visiting the centre for the first time and starting a new treatment regimen) and non naive patients. Results: At enrolment, 84% of patients were taking atypical drugs, 3.7% typical, 10% a combination of the two classes, and 2% were untreated. During follow-up, 23% of patients switched at least once to a different class of treatment, a combination or no treatment. The mean Drug-Attitude-Inventory score was 43.4, with 94.3% of the patients considered compliant by the clinicians. On average, medical costs at baseline were 390.93(sic)/patient-month, mostly for drug treatment (29.5%), psychotherapy Conclusions: Our results suggest how tailoring the treatment strategy according to the complex and specific patient needs make it possible to achieve benefits and to allocate more efficiently resources. This study can also provide information on the most relevant items to be considered when conducting cost-effectiveness studies comparing specific alternatives for the treatment of target patients.
Original languageUndefined/Unknown
JournalBMC Psychiatry
Volume13
DOIs
Publication statusPublished - 2013

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