Composition of cutaneous bacterial microbiome in seborrheic dermatitis patients: A cross-sectional study

Martijn G.H. Sanders; Tamar Nijsten; Joost Verlouw; Robert Kraaij; Luba Pardo Cortes

doi:10.1371/journal.pone.0251136

Composition of cutaneous bacterial microbiome in seborrheic dermatitis patients: A cross-sectional study

Martijn G.H. Sanders, Tamar Nijsten, Joost Verlouw, Robert Kraaij, Luba Pardo Cortes^*

^*Corresponding author for this work

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Abstract

Results We found an increased α-diversity between SD lesional cases versus controls (Shannon diversity: Kruskal-Wallis rank sum: Chi-squared: 19.06; global p-value = 7.7x10^-5). Multivariate statistical analysis showed significant associations in microbiome composition when comparing lesional SD skin to controls (p-value = 0.03;R² = 0.1%). Seven out of 13 amplicon sequence variants (ASVs) that were significantly different between controls and lesional cases were members of the genus Staphylococcus, most of which showed increased composition in lesional cases, and were closely related to S. capitis S. caprae and S. epidermidis. Conclusion Microbiome composition differs in patients with seborrheic dermatitis and individuals without diseases. Differences were mainly found in the genus Staphylococcus.

Original language	English
Article number	e0251136
Journal	PLoS ONE
Volume	16
Issue number	5 May
DOIs	https://doi.org/10.1371/journal.pone.0251136
Publication status	Published - 24 May 2021

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title = "Composition of cutaneous bacterial microbiome in seborrheic dermatitis patients: A cross-sectional study",

abstract = "Results We found an increased α-diversity between SD lesional cases versus controls (Shannon diversity: Kruskal-Wallis rank sum: Chi-squared: 19.06; global p-value = 7.7x10-5). Multivariate statistical analysis showed significant associations in microbiome composition when comparing lesional SD skin to controls (p-value = 0.03;R2 = 0.1%). Seven out of 13 amplicon sequence variants (ASVs) that were significantly different between controls and lesional cases were members of the genus Staphylococcus, most of which showed increased composition in lesional cases, and were closely related to S. capitis S. caprae and S. epidermidis. Conclusion Microbiome composition differs in patients with seborrheic dermatitis and individuals without diseases. Differences were mainly found in the genus Staphylococcus.",

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T1 - Composition of cutaneous bacterial microbiome in seborrheic dermatitis patients

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AU - Sanders, Martijn G.H.

AU - Nijsten, Tamar

AU - Verlouw, Joost

AU - Kraaij, Robert

AU - Pardo Cortes, Luba

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AB - Results We found an increased α-diversity between SD lesional cases versus controls (Shannon diversity: Kruskal-Wallis rank sum: Chi-squared: 19.06; global p-value = 7.7x10-5). Multivariate statistical analysis showed significant associations in microbiome composition when comparing lesional SD skin to controls (p-value = 0.03;R2 = 0.1%). Seven out of 13 amplicon sequence variants (ASVs) that were significantly different between controls and lesional cases were members of the genus Staphylococcus, most of which showed increased composition in lesional cases, and were closely related to S. capitis S. caprae and S. epidermidis. Conclusion Microbiome composition differs in patients with seborrheic dermatitis and individuals without diseases. Differences were mainly found in the genus Staphylococcus.

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Composition of cutaneous bacterial microbiome in seborrheic dermatitis patients: A cross-sectional study

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