Comprehensive two-dimensional liquid chromatography mass spectrometric profiling of the rat hippocampal proteome

XG Yang, Y Levin, H Rahmoune, D Ma, S Schoffmann, Y Umrania, PC Guest, Sabine Bahn

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15 Citations (Scopus)

Abstract

In this study, we performed the first high-throughput and comprehensive proteomic profiling of the rat hippocampal proteome. Using a combination of 2-D LC-MS and data analysis with the Rosetta Elucidator (R) system, we identified 1340 unique proteins. Functional classification showed that most of these were associated with synaptic function and comprised a high proportion of phosphorylated proteins and analytically challenging classes of membrane proteins such as ion channel receptor subunits.
Original languageUndefined/Unknown
Pages (from-to)501-505
Number of pages5
JournalProteomics
Volume11
Issue number3
DOIs
Publication statusPublished - 2011

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