Computational analysis of a microRNA signature for poor prognosis suggests a microRNA-controlled stemness pathway in paediatric acute leukaemia

Stefan J. Erkeland*

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

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Abstract

Esperanza-Cebollada E., et al. found a group of 24 microRNAs, to be differentially expressed between two groups of paediatric acute myeloid leukaemia (AML) cases with distinct outcomes. The main target of this microRNA signature is SOCS2, a gene that controls stemness. The results of this study may open doors for further investigation of the role for microRNAs in poor prognostic paediatric AML. Commentary on: Esperanza-Cebollada et al. A miRNA signature related to stemness identifies high-risk patients in paediatric acute myeloid leukaemia. Br J Haematol 2023;202:96–110.

Original languageEnglish
Pages (from-to)11-12
Number of pages2
JournalBritish Journal of Haematology
Volume202
Issue number1
Early online date30 Mar 2023
DOIs
Publication statusPublished - Jul 2023

Bibliographical note

Publisher Copyright:
© 2023 The Author. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.

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