Congenital aortic stenosis in adults: rate of progression and predictors of clinical outcome: Reply

Sing Chien Yap*, Jolien W. Roos-Hesselink

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

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Abstract

Dear Editor,
We thank Dr. Ramaraj for his interest in our analysis on the progression of congenital aortic stenosis. Age should be regarded as an important risk factor for faster stenosis progression. The mechanism for faster progression is probably valve calcification occurring at an earlier age, promoted by the abnormal mechanical and shear stresses associated with a bicuspid aortic valve. Recent insights into the pathogenesis of calcification of the aortic valve suggest that this is an active, rather than a passive process, with features reminiscent of atherosclerosis. Inflammation, lipid infiltration, dystrophic calcification, ossification, and endothelial dysfunction have been observed in both diseases. [...]
Original languageEnglish
Pages (from-to)213-214
Number of pages2
JournalInternational Journal of Cardiology
Volume138
Issue number2
DOIs
Publication statusPublished - 21 Jan 2010

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