Congenital diaphragmatic hernia: new models, new ideas

A. E. Brandsma; R. Tenbrinck; H. Ijsselstijn; E. C. Scheffers; J. L.J. Gaillard; D. Kluth; A. A.W. ten Have-Opbroek; B. Lachmann; D. Tibboel

doi:10.1007/BF00174434

Congenital diaphragmatic hernia: new models, new ideas

A. E. Brandsma^*, R. Tenbrinck, H. Ijsselstijn, E. C. Scheffers, J. L.J. Gaillard, D. Kluth, A. A.W. ten Have-Opbroek, B. Lachmann, D. Tibboel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

An animal model for congenital diaphragmatic hernia following interference with the development of the primary lung bud by 2,4-dinitro-p-diphenylether (nitrofen) is described. It has been used for pathogenetic studies to evaluate the presence of pulmonary hypoplasia and a closing defect of the diaphragm. Functional studies revealed abnormal surfactant levels and differences in pressure/volume curves following birth and during artificial ventilation for 6 h together with a disturbed antioxidant enzyme response. This animal model opens up new ways of studying the effects of prenatal hormonal modulation (corticosteroids, thyrotrophin-releasing hormone) on lung development as a novel therapeutic modality.

Original language	English
Pages (from-to)	10-15
Number of pages	6
Journal	Pediatric Surgery International
Volume	10
Issue number	1
DOIs	https://doi.org/10.1007/BF00174434
Publication status	Published - Jan 1995

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abstract = "An animal model for congenital diaphragmatic hernia following interference with the development of the primary lung bud by 2,4-dinitro-p-diphenylether (nitrofen) is described. It has been used for pathogenetic studies to evaluate the presence of pulmonary hypoplasia and a closing defect of the diaphragm. Functional studies revealed abnormal surfactant levels and differences in pressure/volume curves following birth and during artificial ventilation for 6 h together with a disturbed antioxidant enzyme response. This animal model opens up new ways of studying the effects of prenatal hormonal modulation (corticosteroids, thyrotrophin-releasing hormone) on lung development as a novel therapeutic modality.",

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T2 - new models, new ideas

AU - Brandsma, A. E.

AU - Tenbrinck, R.

AU - Ijsselstijn, H.

AU - Scheffers, E. C.

AU - Gaillard, J. L.J.

AU - Kluth, D.

AU - ten Have-Opbroek, A. A.W.

AU - Lachmann, B.

AU - Tibboel, D.

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Congenital diaphragmatic hernia: new models, new ideas

Abstract

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