Congenital diaphragmatic hernia: new models, new ideas

A. E. Brandsma*, R. Tenbrinck, H. Ijsselstijn, E. C. Scheffers, J. L.J. Gaillard, D. Kluth, A. A.W. ten Have-Opbroek, B. Lachmann, D. Tibboel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

An animal model for congenital diaphragmatic hernia following interference with the development of the primary lung bud by 2,4-dinitro-p-diphenylether (nitrofen) is described. It has been used for pathogenetic studies to evaluate the presence of pulmonary hypoplasia and a closing defect of the diaphragm. Functional studies revealed abnormal surfactant levels and differences in pressure/volume curves following birth and during artificial ventilation for 6 h together with a disturbed antioxidant enzyme response. This animal model opens up new ways of studying the effects of prenatal hormonal modulation (corticosteroids, thyrotrophin-releasing hormone) on lung development as a novel therapeutic modality.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalPediatric Surgery International
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 1995

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