Consensus definitions in imported human schistosomiasis: a GeoSentinel and TropNet Delphi study

Francesca Tamarozzi*, Cristina Mazzi, Spinello Antinori, Marta Arsuaga, Sören L. Becker, Emmanuel Bottieau, Daniel Camprubi-Ferrer, Eric Caumes, Alexandre Duvignaud, Martin P. Grobusch, Stephane Jaureguiberry, Sabine Jordan, Andreas Mueller, Andreas Neumayr, Jose A. Perez-Molina, Joaquin Salas-Coronas, Fernando Salvador, Lina R. Tomasoni, Jaap J. van Hellemond, Stephen D. VaughanLinda J. Wammes, Lorenzo Zammarchi, Dora Buonfrate, Ralph Huits, Lisette van Lieshout, Federico Gobbi

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Terminology in schistosomiasis is not harmonised, generating misunderstanding in data interpretation and clinical descriptions. This study aimed to achieve consensus on definitions of clinical aspects of schistosomiasis in migrants and returning travellers. We applied the Delphi method. Experts from institutions affiliated with GeoSentinel and TropNet, identified through clinical and scientific criteria, were invited to participate. Five external reviewers revised and pilot-tested the statements. Statements focusing on the definitions of acute or chronic; possible, probable, or confirmed; active; and complicated schistosomiasis were managed through REDCap and replies managed in a blinded manner. Round 1 mapped the definitions used by experts; subsequent rounds were done to reach consensus, or quantify disagreement, on the proposed statements. Data were analysed with percentages, medians, and IQRs of a 5-point Likert scale. The study was terminated on the basis of consensus or stability-related and time-related criteria. 28 clinicians and scientists met the criteria for experts. 25 (89%) of 28 experts replied to Round 1, 18 (64%) of 28 to Round 2, 19 (68%) of 28 to Round 3, and 21 (75%) of 28 to at least two rounds. High-level consensus (79–100% agreement and IQRs ≤1) was reached for all definitions. Consensus definitions will foster harmonised scientific and clinical communication and support future research and development of management guidelines for schistosomiasis.

Original languageEnglish
JournalThe Lancet Infectious Diseases
DOIs
Publication statusE-pub ahead of print - 8 Mar 2024

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© 2024 Elsevier Ltd

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