Abstract
The epidermal growth factor receptor (EGFR) has been shown to play an important role in brain development, including stem and precursor cell survival, proliferation, differentiation, and migration. To further examine the temporal and spatial requirements of erbB signals in uncommitted neural stem cells (NSCs), we expressed the ligand-independent EGF receptor, EGFRvIII, in C17.2 NSCs. These NSCs are known to migrate and to evince a tropic response to neurodegenerative environments in vivo but for which an underlying mechanism remains unclear. We show that enhanced erbB signaling via constitutive kinase activity of EGFRvIII in NSCs sustains an immature phenotype and enhances NSC migration.
Original language | English |
---|---|
Pages (from-to) | 1116-1130 |
Number of pages | 15 |
Journal | Molecular and Cellular Neuroscience |
Volume | 24 |
Issue number | 4 |
DOIs | |
Publication status | Published - Dec 2003 |
Externally published | Yes |