Constitutive EGFR signaling confers a motile phenotype to neural stem cells

John A. Boockvar*, Dmitri Kapitonov, Gurpreet Kapoor, Joost Schouten, George J. Counelis, Oliver Bogler, Evan Y. Snyder, Tracy K. McIntosh, Donald M. O'Rourke

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

105 Citations (Scopus)

Abstract

The epidermal growth factor receptor (EGFR) has been shown to play an important role in brain development, including stem and precursor cell survival, proliferation, differentiation, and migration. To further examine the temporal and spatial requirements of erbB signals in uncommitted neural stem cells (NSCs), we expressed the ligand-independent EGF receptor, EGFRvIII, in C17.2 NSCs. These NSCs are known to migrate and to evince a tropic response to neurodegenerative environments in vivo but for which an underlying mechanism remains unclear. We show that enhanced erbB signaling via constitutive kinase activity of EGFRvIII in NSCs sustains an immature phenotype and enhances NSC migration.

Original languageEnglish
Pages (from-to)1116-1130
Number of pages15
JournalMolecular and Cellular Neuroscience
Volume24
Issue number4
DOIs
Publication statusPublished - Dec 2003
Externally publishedYes

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