Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs

Annette Caenen*, Lana Keijzer, Stéphanie Bézy, Jürgen Duchenne, Marta Orlowska, Antonius F.W. Van Der Steen, Nico De Jong, Johan G. Bosch, Jens Uwe Voigt, Jan D’hooge, Hendrik J. Vos

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
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Abstract

Ultrasound-based shear wave elastography is a promising technique to non-invasively assess the dynamic stiffness variations of the heart. The technique is based on tracking the propagation of acoustically induced shear waves in the myocardium of which the propagation speed is linked to tissue stiffness. This measurement is repeated multiple times across the cardiac cycle to assess the natural variations in wave propagation speed. The interpretation of these measurements remains however complex, as factors such as loading and contractility affect wave propagation. We therefore applied transthoracic shear wave elastography in 13 pigs to investigate the dependencies of wave speed on pressure–volume derived indices of loading, myocardial stiffness, and contractility, while altering loading and inducing myocardial ischemia/reperfusion injury. Our results show that diastolic wave speed correlates to a pressure–volume derived index of operational myocardial stiffness (R = 0.75, p < 0.001), suggesting that both loading and intrinsic properties can affect diastolic wave speed. Additionally, the wave speed ratio, i.e. the ratio of systolic and diastolic speed, correlates to a pressure–volume derived index of contractility, i.e. preload-recruitable stroke work (R = 0.67, p < 0.001). Measuring wave speed ratio might thus provide a non-invasive index of contractility during ischemia/reperfusion injury.

Original languageEnglish
Article number17660
JournalScientific Reports
Volume13
Issue number1
DOIs
Publication statusPublished - 17 Oct 2023

Bibliographical note

Funding Information:
This work was supported by the Research Foundation Flanders (FWO, Brussels, Belgium) under Grant 1211620N to Annette Caenen and, Grants G092318N and 1832922N to Jens-Uwe Voigt. This work is also part of the TTW–Dutch Heart Foundation partnership program ‘Earlier recognition of cardiovascular diseases’ with project number 14740.

Publisher Copyright:
© 2023, Springer Nature Limited.

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