TY - GEN
T1 - Contrast-enhanced intravascular ultrasound 3D reconstruction of a vasa vasorum mimicking model
AU - Maresca, David
AU - Emmer, Marcia
AU - Springeling, Geert
AU - Mastik, Frits
AU - Van Soest, Gijs
AU - De Jong, Nico
AU - Van Der Steen, Antonius F.W.
PY - 2010
Y1 - 2010
N2 - It is increasingly recognized that the development of new microvessels (vasa vasorum) within and surrounding atherosclerotic plaques is essential to enable artery lesion growth and plays a central role in rendering it vulnerable to rupture. Currently, there is no established clinical technique capable of imaging the vasa vasorum (VV) in the coronary arteries of humans. It has been shown that contrast-enhanced intravascular ultrasound (CE-IVUS) is capable of imaging VV in vivo. This study aims at reconstructing in three dimensions (3D) a VV model using CE-IVUS with a clinical coronary imaging catheter. A polyvinyl alcohol based VV model was manufactured, exhibiting a VV mimicking branch pattern with a diameter ranging from 200 to 100 um. After perfusion of the VV model with the ultrasound contrast agent Definity, a manual pullback consisting of 93 cross sectional IVUS images spaced every 200 m was performed. Perfused areas were segmented in two registered CE-IVUS planes and compared to coregistered 10 um thick slices of the VV model. The VV mimicking microchannel diameters measured with CE-IVUS agreed within 30% with the slice diameters. As CE-IVUS imaging can be carried out in-vivo, this method could be used during clinical IVUS investigations as an additional diagnostic for plaque vulnerability.
AB - It is increasingly recognized that the development of new microvessels (vasa vasorum) within and surrounding atherosclerotic plaques is essential to enable artery lesion growth and plays a central role in rendering it vulnerable to rupture. Currently, there is no established clinical technique capable of imaging the vasa vasorum (VV) in the coronary arteries of humans. It has been shown that contrast-enhanced intravascular ultrasound (CE-IVUS) is capable of imaging VV in vivo. This study aims at reconstructing in three dimensions (3D) a VV model using CE-IVUS with a clinical coronary imaging catheter. A polyvinyl alcohol based VV model was manufactured, exhibiting a VV mimicking branch pattern with a diameter ranging from 200 to 100 um. After perfusion of the VV model with the ultrasound contrast agent Definity, a manual pullback consisting of 93 cross sectional IVUS images spaced every 200 m was performed. Perfused areas were segmented in two registered CE-IVUS planes and compared to coregistered 10 um thick slices of the VV model. The VV mimicking microchannel diameters measured with CE-IVUS agreed within 30% with the slice diameters. As CE-IVUS imaging can be carried out in-vivo, this method could be used during clinical IVUS investigations as an additional diagnostic for plaque vulnerability.
UR - https://www.scopus.com/pages/publications/80054736614
U2 - 10.1109/ULTSYM.2010.5935756
DO - 10.1109/ULTSYM.2010.5935756
M3 - Conference proceeding
AN - SCOPUS:80054736614
SN - 9781457703829
T3 - Proceedings of the IEEE Ultrasonics Symposium
SP - 2364
EP - 2367
BT - 2010 IEEE International Ultrasonics Symposium, IUS 2010
T2 - 2010 IEEE International Ultrasonics Symposium, IUS 2010
Y2 - 11 October 2010 through 14 October 2010
ER -