Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder

Florian Bootsman; Rachel M. Brouwer; Sanne M. Kemner; Hugo G. Schnack; Astrid C. van der Schot; Ronald Vonk; Manon H.J. Hillegers; Dorret I. Boomsma; Hilleke E. Hulshoff Pol; Willem A. Nolen; René S. Kahn; Neeltje E.M. van Haren

doi:10.1016/j.euroneuro.2015.09.023

Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder

Florian Bootsman^*, Rachel M. Brouwer, Sanne M. Kemner, Hugo G. Schnack, Astrid C. van der Schot, Ronald Vonk, Manon H.J. Hillegers, Dorret I. Boomsma, Hilleke E. Hulshoff Pol, Willem A. Nolen, René S. Kahn, Neeltje E.M. van Haren

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

The influence of genes and environment on the association between bipolar disorder (BD) and volumes of subcortical brain regions involved in emotion processing has rarely been studied. Furthermore, as far as we know, longitudinal twin studies of subcortical brain volume change in BD have not been carried out at all. In this study, we focused on the genetic and environmental contributions to cross-sectional and longitudinal measures of subcortical brain volumes in BD.A total of 99 twins from monozygotic and dizygotic pairs concordant or discordant for BD and 129 twins from monozygotic and dizygotic healthy control pairs underwent magnetic resonance imaging at baseline. Longitudinal assessment was carried out in 48 twins from monozygotic and dizygotic patient pairs and 52 twins from monozygotic and dizygotic control pairs. Subcortical volume measures were obtained with Freesurfer software and analyzed with structural equation modeling software OpenMx.At baseline, BD was phenotypically and genetically associated with smaller volumes of the thalamus, putamen and nucleus accumbens. BD was not associated with subcortical brain volume change over time in any of the examined regions. Heritability of subcortical volumes at baseline was high, whereas subcortical volume change had low heritability.Genes contributing to BD showed overlap with those associated with smaller volumes of the thalamus, putamen and nucleus accumbens at baseline. Further evaluation of genetic contributions to abnormalities in subcortical brain regions assumed to be involved in emotion processing is recommended.

Original language	English
Pages (from-to)	2197-2209
Number of pages	13
Journal	European Neuropsychopharmacology
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/j.euroneuro.2015.09.023
Publication status	Published - 1 Dec 2015
Externally published	Yes

Bibliographical note

Funding Information:
We thank the Netherlands Organization for Scientific Research (NWO) for supporting this study (Grant 9120818 ). We thank Raissa Derckx for her assistance with the quality checking of MRI data.

Funding Information:
Funding for this study was provided by the Netherlands Organization for Scientific Research (NWO), Grant 9120818. The NWO had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

Publisher Copyright:
© 2015 Elsevier B.V. and ECNP.

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Bootsman, F., Brouwer, R. M., Kemner, S. M., Schnack, H. G., van der Schot, A. C., Vonk, R., Hillegers, M. H. J., Boomsma, D. I., Hulshoff Pol, H. E., Nolen, W. A., Kahn, R. S., & van Haren, N. E. M. (2015). Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder. European Neuropsychopharmacology, 25(12), 2197-2209. https://doi.org/10.1016/j.euroneuro.2015.09.023

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title = "Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder",

abstract = "The influence of genes and environment on the association between bipolar disorder (BD) and volumes of subcortical brain regions involved in emotion processing has rarely been studied. Furthermore, as far as we know, longitudinal twin studies of subcortical brain volume change in BD have not been carried out at all. In this study, we focused on the genetic and environmental contributions to cross-sectional and longitudinal measures of subcortical brain volumes in BD.A total of 99 twins from monozygotic and dizygotic pairs concordant or discordant for BD and 129 twins from monozygotic and dizygotic healthy control pairs underwent magnetic resonance imaging at baseline. Longitudinal assessment was carried out in 48 twins from monozygotic and dizygotic patient pairs and 52 twins from monozygotic and dizygotic control pairs. Subcortical volume measures were obtained with Freesurfer software and analyzed with structural equation modeling software OpenMx.At baseline, BD was phenotypically and genetically associated with smaller volumes of the thalamus, putamen and nucleus accumbens. BD was not associated with subcortical brain volume change over time in any of the examined regions. Heritability of subcortical volumes at baseline was high, whereas subcortical volume change had low heritability.Genes contributing to BD showed overlap with those associated with smaller volumes of the thalamus, putamen and nucleus accumbens at baseline. Further evaluation of genetic contributions to abnormalities in subcortical brain regions assumed to be involved in emotion processing is recommended.",

author = "Florian Bootsman and Brouwer, {Rachel M.} and Kemner, {Sanne M.} and Schnack, {Hugo G.} and {van der Schot}, {Astrid C.} and Ronald Vonk and Hillegers, {Manon H.J.} and Boomsma, {Dorret I.} and {Hulshoff Pol}, {Hilleke E.} and Nolen, {Willem A.} and Kahn, {Ren{\'e} S.} and {van Haren}, {Neeltje E.M.}",

note = "Funding Information: We thank the Netherlands Organization for Scientific Research (NWO) for supporting this study (Grant 9120818 ). We thank Raissa Derckx for her assistance with the quality checking of MRI data. Funding Information: Funding for this study was provided by the Netherlands Organization for Scientific Research (NWO), Grant 9120818. The NWO had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Publisher Copyright: {\textcopyright} 2015 Elsevier B.V. and ECNP.",

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doi = "10.1016/j.euroneuro.2015.09.023",

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Bootsman, F, Brouwer, RM, Kemner, SM, Schnack, HG, van der Schot, AC, Vonk, R, Hillegers, MHJ, Boomsma, DI, Hulshoff Pol, HE, Nolen, WA, Kahn, RS & van Haren, NEM 2015, 'Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder', European Neuropsychopharmacology, vol. 25, no. 12, pp. 2197-2209. https://doi.org/10.1016/j.euroneuro.2015.09.023

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T1 - Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder

AU - Bootsman, Florian

AU - Brouwer, Rachel M.

AU - Kemner, Sanne M.

AU - Schnack, Hugo G.

AU - van der Schot, Astrid C.

AU - Vonk, Ronald

AU - Hillegers, Manon H.J.

AU - Boomsma, Dorret I.

AU - Hulshoff Pol, Hilleke E.

AU - Nolen, Willem A.

AU - Kahn, René S.

AU - van Haren, Neeltje E.M.

N1 - Funding Information: We thank the Netherlands Organization for Scientific Research (NWO) for supporting this study (Grant 9120818 ). We thank Raissa Derckx for her assistance with the quality checking of MRI data. Funding Information: Funding for this study was provided by the Netherlands Organization for Scientific Research (NWO), Grant 9120818. The NWO had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Publisher Copyright: © 2015 Elsevier B.V. and ECNP.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The influence of genes and environment on the association between bipolar disorder (BD) and volumes of subcortical brain regions involved in emotion processing has rarely been studied. Furthermore, as far as we know, longitudinal twin studies of subcortical brain volume change in BD have not been carried out at all. In this study, we focused on the genetic and environmental contributions to cross-sectional and longitudinal measures of subcortical brain volumes in BD.A total of 99 twins from monozygotic and dizygotic pairs concordant or discordant for BD and 129 twins from monozygotic and dizygotic healthy control pairs underwent magnetic resonance imaging at baseline. Longitudinal assessment was carried out in 48 twins from monozygotic and dizygotic patient pairs and 52 twins from monozygotic and dizygotic control pairs. Subcortical volume measures were obtained with Freesurfer software and analyzed with structural equation modeling software OpenMx.At baseline, BD was phenotypically and genetically associated with smaller volumes of the thalamus, putamen and nucleus accumbens. BD was not associated with subcortical brain volume change over time in any of the examined regions. Heritability of subcortical volumes at baseline was high, whereas subcortical volume change had low heritability.Genes contributing to BD showed overlap with those associated with smaller volumes of the thalamus, putamen and nucleus accumbens at baseline. Further evaluation of genetic contributions to abnormalities in subcortical brain regions assumed to be involved in emotion processing is recommended.

AB - The influence of genes and environment on the association between bipolar disorder (BD) and volumes of subcortical brain regions involved in emotion processing has rarely been studied. Furthermore, as far as we know, longitudinal twin studies of subcortical brain volume change in BD have not been carried out at all. In this study, we focused on the genetic and environmental contributions to cross-sectional and longitudinal measures of subcortical brain volumes in BD.A total of 99 twins from monozygotic and dizygotic pairs concordant or discordant for BD and 129 twins from monozygotic and dizygotic healthy control pairs underwent magnetic resonance imaging at baseline. Longitudinal assessment was carried out in 48 twins from monozygotic and dizygotic patient pairs and 52 twins from monozygotic and dizygotic control pairs. Subcortical volume measures were obtained with Freesurfer software and analyzed with structural equation modeling software OpenMx.At baseline, BD was phenotypically and genetically associated with smaller volumes of the thalamus, putamen and nucleus accumbens. BD was not associated with subcortical brain volume change over time in any of the examined regions. Heritability of subcortical volumes at baseline was high, whereas subcortical volume change had low heritability.Genes contributing to BD showed overlap with those associated with smaller volumes of the thalamus, putamen and nucleus accumbens at baseline. Further evaluation of genetic contributions to abnormalities in subcortical brain regions assumed to be involved in emotion processing is recommended.

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Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder

Abstract

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