Contributions of Wall Stretch and Shear Stress to Vascular Regulation: Molecular Mechanisms of Homeostasis and Expansion

Ranganath Maringanti; Elana Meijer; Maarten M. Brandt; Dirk J. Duncker; Caroline Cheng

doi:10.1007/978-3-030-63164-2_2

Contributions of Wall Stretch and Shear Stress to Vascular Regulation: Molecular Mechanisms of Homeostasis and Expansion

Ranganath Maringanti, Elana Meijer, Maarten M. Brandt, Dirk J. Duncker, Caroline Cheng^*

^*Corresponding author for this work

Cardiology

Research output: Chapter/Conference proceeding › Chapter › Academic

Abstract

Blood vessels are continuously exposed to hemodynamic forces due to the pulsatile nature of the blood flow. In normal physiological settings, these forces are essential in the maintenance of vascular cell function and structure, vascular growth, and in the regulation of vascular tone. However, when exceeding the physiological range these biomechanical forces become detrimental and may initiate pathological pathways. In this chapter, we discuss the types of vascular biomechanical forces, unravel cellular and molecular mechanisms underlying the physiological and pathophysiological response of the vascular cells to these biomechanical stimuli, and describe their role in triggering vascular growth.

Original language	English
Title of host publication	Cardiac and Vascular Biology
Publisher	Springer Science+Business Media
Pages	21-46
Number of pages	26
DOIs	https://doi.org/10.1007/978-3-030-63164-2_2
Publication status	Published - 2021

Publication series

Series	Cardiac and Vascular Biology
Volume	8
ISSN	2509-7830

Bibliographical note

Funding Information:
Compliance with Ethical Standards Sources of Funding: This work was supported by the

Publisher Copyright:
© 2021, Springer Nature Switzerland AG.

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10.1007/978-3-030-63164-2_2

Cite this

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author = "Ranganath Maringanti and Elana Meijer and Brandt, {Maarten M.} and Duncker, {Dirk J.} and Caroline Cheng",

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Contributions of Wall Stretch and Shear Stress to Vascular Regulation: Molecular Mechanisms of Homeostasis and Expansion. / Maringanti, Ranganath; Meijer, Elana; Brandt, Maarten M. et al.
Cardiac and Vascular Biology. Springer Science+Business Media, 2021. p. 21-46 (Cardiac and Vascular Biology, Vol. 8).

Research output: Chapter/Conference proceeding › Chapter › Academic

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Contributions of Wall Stretch and Shear Stress to Vascular Regulation: Molecular Mechanisms of Homeostasis and Expansion

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