Conversion of senescent cartilage into a pro-chondrogenic microenvironment with antibody-functionalized copper sulfate nanoparticles for efficient osteoarthritis therapy

Xianming Wang, Yu Cai, Cuixi Wu, Jiamin Liang, Kangning Tang, Zefeng Lin, Lingling Chen, Yao Lu*, Qing Wang*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)
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Abstract

The development of osteoarthritis (OA) correlates with the expansion of senescent cells in cartilage, which contributes to an inflammatory microenvironment that accelerates matrix degradation and hampers cartilage generation. To address OA, we synthesized small copper sulfide nanoparticles functionalized with anti-beta-2-microglobulin antibodies (B2M-CuS NPs) that catalyze the formation of toxic •OH from H2O2 via peroxidase-like activity. These B2M-CuS NPs are specifically targeted to induce apoptosis in senescent chondrocytes while showing no toxicity toward normal chondrocytes. Furthermore, B2M-CuS NPs enhance the chondrogenesis of normal chondrocytes. Thus, B2M-CuS NPs can effectively treat OA by clearing senescent chondrocytes and promoting cartilage regeneration after intra-articular injection into the knee joints of surgery-induced OA mice. This study uses smart nanomaterials to treat OA with a synergistic strategy that both remodels senescent cartilage and creates a pro-chondrogenic microenvironment.

Original languageEnglish
Article number258
JournalJournal of Nanobiotechnology
Volume21
Issue number1
DOIs
Publication statusPublished - 8 Aug 2023
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by the Plan on Enhancing Scientific Research in GMU, Guangzhou Clinical Characteristic Technology Project, and Postdoctoral Science Foundation of China (2018M643893).

Publisher Copyright:
© 2023, BioMed Central Ltd., part of Springer Nature.

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