Abstract
The development of osteoarthritis (OA) correlates with the expansion of senescent cells in cartilage, which contributes to an inflammatory microenvironment that accelerates matrix degradation and hampers cartilage generation. To address OA, we synthesized small copper sulfide nanoparticles functionalized with anti-beta-2-microglobulin antibodies (B2M-CuS NPs) that catalyze the formation of toxic •OH from H2O2 via peroxidase-like activity. These B2M-CuS NPs are specifically targeted to induce apoptosis in senescent chondrocytes while showing no toxicity toward normal chondrocytes. Furthermore, B2M-CuS NPs enhance the chondrogenesis of normal chondrocytes. Thus, B2M-CuS NPs can effectively treat OA by clearing senescent chondrocytes and promoting cartilage regeneration after intra-articular injection into the knee joints of surgery-induced OA mice. This study uses smart nanomaterials to treat OA with a synergistic strategy that both remodels senescent cartilage and creates a pro-chondrogenic microenvironment.
Original language | English |
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Article number | 258 |
Journal | Journal of Nanobiotechnology |
Volume | 21 |
Issue number | 1 |
DOIs | |
Publication status | Published - 8 Aug 2023 |
Externally published | Yes |
Bibliographical note
Funding Information:This study was supported by the Plan on Enhancing Scientific Research in GMU, Guangzhou Clinical Characteristic Technology Project, and Postdoctoral Science Foundation of China (2018M643893).
Publisher Copyright:
© 2023, BioMed Central Ltd., part of Springer Nature.