Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study

LM McGrath, DM Yu, C Marshall, LK Davis, B Thiruvahindrapuram, BB Li, C Cappi, G Gerber, A Wolf, FA Schroeder, L Osiecki, C O'Dushlaine, A Kirby, C Illmann, S Haddad, P Gallagher, JA Fagerness, CL Barr, L Bellodi, F BenarrochOJ Bienvenu, DW Black, MH Bloch, RD Bruun, CL Budman, B Camarena, DC Cath, MC Cavallini, S Chouinard, V Coric, B Cullen, R Delorme, D Denys, EM Derks, Y Dion, MC Rosario, V Eapen, P Evans, P Falkai, TV Fernandez, H Garrido, D Geller, HJ Grabe, MA Grados, BD Greenberg, V Gross-Tsur, E Gruenblatt, GA Heiman, SMJ Hemmings, LD Herrera, AG Hounie, J Jankovic, JL Kennedy, RA King, R Kurlan, N Lanzagorta, M Leboyer, JF Leckman, L Lennertz, C Lochner, TL Lowe, GJ Lyon, F Macciardi, W Maier, JT McCracken, W McMahon, DL Murphy, AL Naarden, BM Neale, E Nurmi, AJ Pakstis, MT Pato, CN Pato, J Piacentini, C Pittenger, Y Pollak, VI Reus, MA Richter, M Riddle, MM Robertson, D Rosenberg, GA Rouleau, S Ruhrmann, AS Sampaio, J Samuels, P Sandor, B Sheppard, HS Singer, JH Smit, DJ Stein, JA Tischrield, H Vallada, J Veenstra-VanderWeele, S Walitza, YA Wang, JR Wendfand, YY Shugart, EC Miguel, H Nicolini, Ben Oostra, R Moessner, M Wagner, A Ruiz-Linares, P Heutink, G Nestadt, N Freimer, T Petryshen, Daniëlle Posthuma, MA Jenike, NJ Cox, GL Hanna, H Brentani, SW Scherer, PD Arnold, SE Stewart, CA Mathews, JA Knowles, EH Cook, DL Pauls, K Wang, JM Scharf

Research output: Contribution to journalArticleAcademicpeer-review

70 Citations (Scopus)

Abstract

Objective: Obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) are heritable neurodevelopmental disorders with a partially shared genetic etiology. This study represents the first genome-wide investigation of large (>500 kb), rare (<1%) copy number variants (CNVs) in OCD and the largest genome-wide CNV analysis in TS to date. Method: The primary analyses used a cross-disorder design for 2,699 case patients (1,613 ascertained for OCD, 1,086 ascertained for TS) and 1,789 controls. Parental data facilitated a de novo analysis in 348 OCD trios. Results: Although no global CNV burden was detected in the cross-disorder analysis or in secondary, disease-specific analyses, there was a 3.3-fold increased burden of large deletions previously associated with other neurodevelopmental disorders (p = .09). Half of these neurodevelopmental deletions were located in a single locus, 16p13.11 (5 case patient deletions: 0 control deletions, p = .08 in the current study, p = .025 compared to published controls). Three 16p13.11 deletions were confirmed de novo, providing further support for the etiological significance of this region. The overall OCD de novo rate was 1.4%, which is intermediate between published rates in controls (0.7%) and in individuals with autism or schizophrenia (2-4%). Conclusion: Several converging lines of evidence implicate 16p13.11 deletions in OCD, with weaker evidence for a role in TS. The trend toward increased overall neurodevelopmental CNV burden in TS and OCD suggests that deletions previously associated with other neurodevelopmental disorders may also contribute to these phenotypes.
Original languageUndefined/Unknown
Pages (from-to)910-919
Number of pages10
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume53
Issue number8
DOIs
Publication statusPublished - 2014

Cite this