TY - JOUR
T1 - Cord Blood Metabolite Profiles and Their Association with Autistic Traits in Childhood
AU - Kaupper, Christin S.
AU - Blaauwendraad, Sophia M.
AU - Cecil, Charlotte A.M.
AU - Mulder, Rosa H.
AU - Gaillard, Romy
AU - Goncalves, Romy
AU - Borggraefe, Ingo
AU - Koletzko, Berthold
AU - Jaddoe, Vincent W.V.
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/11/9
Y1 - 2023/11/9
N2 - Autism Spectrum Disorder (ASD) is a diverse neurodevelopmental condition. Gene–environmental interactions in early stages of life might alter metabolic pathways, possibly contributing to ASD pathophysiology. Metabolomics may serve as a tool to identify underlying metabolic mechanisms contributing to ASD phenotype and could help to unravel its complex etiology. In a population-based, prospective cohort study among 783 mother–child pairs, cord blood serum concentrations of amino acids, non-esterified fatty acids, phospholipids, and carnitines were obtained using liquid chromatography coupled with tandem mass spectrometry. Autistic traits were measured at the children’s ages of 6 (n = 716) and 13 (n = 648) years using the parent-reported Social Responsiveness Scale. Lower cord blood concentrations of SM.C.39.2 and NEFA16:1/16:0 were associated with higher autistic traits among 6-year-old children, adjusted for sex and age at outcome. After more stringent adjustment for confounders, no significant associations of cord blood metabolites and autistic traits at ages 6 and 13 were detected. Differences in lipid metabolism (SM and NEFA) might be involved in ASD-related pathways and are worth further investigation.
AB - Autism Spectrum Disorder (ASD) is a diverse neurodevelopmental condition. Gene–environmental interactions in early stages of life might alter metabolic pathways, possibly contributing to ASD pathophysiology. Metabolomics may serve as a tool to identify underlying metabolic mechanisms contributing to ASD phenotype and could help to unravel its complex etiology. In a population-based, prospective cohort study among 783 mother–child pairs, cord blood serum concentrations of amino acids, non-esterified fatty acids, phospholipids, and carnitines were obtained using liquid chromatography coupled with tandem mass spectrometry. Autistic traits were measured at the children’s ages of 6 (n = 716) and 13 (n = 648) years using the parent-reported Social Responsiveness Scale. Lower cord blood concentrations of SM.C.39.2 and NEFA16:1/16:0 were associated with higher autistic traits among 6-year-old children, adjusted for sex and age at outcome. After more stringent adjustment for confounders, no significant associations of cord blood metabolites and autistic traits at ages 6 and 13 were detected. Differences in lipid metabolism (SM and NEFA) might be involved in ASD-related pathways and are worth further investigation.
UR - https://www.scopus.com/pages/publications/85178124343
U2 - 10.3390/metabo13111140
DO - 10.3390/metabo13111140
M3 - Article
C2 - 37999236
AN - SCOPUS:85178124343
SN - 2218-1989
VL - 13
JO - Metabolites
JF - Metabolites
IS - 11
M1 - 1140
ER -
