Cord blood transplantation for adult mature lymphoid neoplasms in Europe and Japan

Mizuki Watanabe; Junya Kanda; Fernanda Volt; Annalisa Ruggeri; Ritsuro Suzuki; Hanadi Rafii; Fumihiko Kimura; Barbara Cappelli; Eisei Kondo; Graziana Maria Scigliuolo; Satoshi Takahashi; Chantal Kenzey; Monica M. Rivera-Franco; Shinichiro Okamoto; Vanderson Rocha; Patrice Chevallier; Jaime Sanz; Sabine Fürst; Jan Cornelissen; Noel Milpied; Naoyuki Uchida; Yasuhiro Sugio; Takafumi Kimura; Tatsuo Ichinohe; Takahiro Fukuda; Mohamad Mohty; Régis Peffault de Latour; Yoshiko Atsuta; Eliane Gluckman

doi:10.1182/bloodadvances.2023010598

Cord blood transplantation for adult mature lymphoid neoplasms in Europe and Japan

Mizuki Watanabe, Junya Kanda^*, Fernanda Volt, Annalisa Ruggeri, Ritsuro Suzuki, Hanadi Rafii, Fumihiko Kimura, Barbara Cappelli, Eisei Kondo, Graziana Maria Scigliuolo, Satoshi Takahashi, Chantal Kenzey, Monica M. Rivera-Franco, Shinichiro Okamoto, Vanderson Rocha, Patrice Chevallier, Jaime Sanz, Sabine Fürst, Jan Cornelissen, Noel MilpiedNaoyuki Uchida, Yasuhiro Sugio, Takafumi Kimura, Tatsuo Ichinohe, Takahiro Fukuda, Mohamad Mohty, Régis Peffault de Latour, Yoshiko Atsuta, Eliane Gluckman

^*Corresponding author for this work

Hematology

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Abstract

To clarify the different characteristics and prognostic factors of cord blood transplantation (CBT) in adult patients with lymphoid neoplasms in Europe and Japan, we conducted a collaborative study. Patients aged 18-75 years receiving their first CBT (Europe: single CBT, n = 192; double CBT, n = 304; Japan: single CBT, n = 1150) in 2000-2017 were analyzed. Fewer patients with Hodgkin lymphoma (Europe vs Japan, 26% vs 5%), and older patients (≥50 years) (39% vs 59%) with a higher refined disease risk index (rDRI) (high-very high: 49% vs 14%) were included in the Japanese registry. High-very high rDRI was associated with inferior overall survival (OS) (vs low rDRI, Europe: hazard ratio [HR], 1.87; P = .001; Japan: HR, 2.34; P < .001) with higher progression/relapse risks. Total body irradiation (TBI)–containing conditioning contributed to superior OS both in Europe (vs TBI–reduced-intensity conditioning [RIC], non-TBI-RIC: HR, 1.93; P < .001; non-TBI–Myeloablative conditioning [MAC]: HR, 1.90; P = .003) and Japan (non–TBI-RIC: HR, 1.71; P < .001; non–TBI-MAC: HR 1.50, P = .007). The impact of HLA mismatches (≥2) on OS differed (Europe: HR, 1.52; P = .007; Japan: HR, 1.18; P = .107). CBT for lymphoid neoplasms, especially in those with high rDRI showed poor outcomes despite all the different characteristics in both registries. TBI should be considered in conditioning regimens to improve these outcomes. The different impacts of HLA mismatches call attention to the fundamental differences among these populations.

Original language	English
Pages (from-to)	640-552
Number of pages	89
Journal	Blood Advances
Volume	8
Issue number	3
DOIs	https://doi.org/10.1182/bloodadvances.2023010598
Publication status	Published - 13 Feb 2024

Bibliographical note

Publisher Copyright:
© 2024 by The American Society of Hematology.

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Watanabe, M., Kanda, J., Volt, F., Ruggeri, A., Suzuki, R., Rafii, H., Kimura, F., Cappelli, B., Kondo, E., Scigliuolo, G. M., Takahashi, S., Kenzey, C., Rivera-Franco, M. M., Okamoto, S., Rocha, V., Chevallier, P., Sanz, J., Fürst, S., Cornelissen, J., ... Gluckman, E. (2024). Cord blood transplantation for adult mature lymphoid neoplasms in Europe and Japan. Blood Advances, 8(3), 640-552. https://doi.org/10.1182/bloodadvances.2023010598

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title = "Cord blood transplantation for adult mature lymphoid neoplasms in Europe and Japan",

abstract = "To clarify the different characteristics and prognostic factors of cord blood transplantation (CBT) in adult patients with lymphoid neoplasms in Europe and Japan, we conducted a collaborative study. Patients aged 18-75 years receiving their first CBT (Europe: single CBT, n = 192; double CBT, n = 304; Japan: single CBT, n = 1150) in 2000-2017 were analyzed. Fewer patients with Hodgkin lymphoma (Europe vs Japan, 26\% vs 5\%), and older patients (≥50 years) (39\% vs 59\%) with a higher refined disease risk index (rDRI) (high-very high: 49\% vs 14\%) were included in the Japanese registry. High-very high rDRI was associated with inferior overall survival (OS) (vs low rDRI, Europe: hazard ratio [HR], 1.87; P = .001; Japan: HR, 2.34; P < .001) with higher progression/relapse risks. Total body irradiation (TBI)–containing conditioning contributed to superior OS both in Europe (vs TBI–reduced-intensity conditioning [RIC], non-TBI-RIC: HR, 1.93; P < .001; non-TBI–Myeloablative conditioning [MAC]: HR, 1.90; P = .003) and Japan (non–TBI-RIC: HR, 1.71; P < .001; non–TBI-MAC: HR 1.50, P = .007). The impact of HLA mismatches (≥2) on OS differed (Europe: HR, 1.52; P = .007; Japan: HR, 1.18; P = .107). CBT for lymphoid neoplasms, especially in those with high rDRI showed poor outcomes despite all the different characteristics in both registries. TBI should be considered in conditioning regimens to improve these outcomes. The different impacts of HLA mismatches call attention to the fundamental differences among these populations.",

author = "Mizuki Watanabe and Junya Kanda and Fernanda Volt and Annalisa Ruggeri and Ritsuro Suzuki and Hanadi Rafii and Fumihiko Kimura and Barbara Cappelli and Eisei Kondo and Scigliuolo, \{Graziana Maria\} and Satoshi Takahashi and Chantal Kenzey and Rivera-Franco, \{Monica M.\} and Shinichiro Okamoto and Vanderson Rocha and Patrice Chevallier and Jaime Sanz and Sabine F{\"u}rst and Jan Cornelissen and Noel Milpied and Naoyuki Uchida and Yasuhiro Sugio and Takafumi Kimura and Tatsuo Ichinohe and Takahiro Fukuda and Mohamad Mohty and \{de Latour\}, \{R{\'e}gis Peffault\} and Yoshiko Atsuta and Eliane Gluckman",

note = "Publisher Copyright: {\textcopyright} 2024 by The American Society of Hematology.",

year = "2024",

month = feb,

day = "13",

doi = "10.1182/bloodadvances.2023010598",

language = "English",

volume = "8",

pages = "640--552",

journal = "Blood Advances",

issn = "2473-9529",

publisher = "American Society of Hematology",

number = "3",

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Watanabe, M, Kanda, J, Volt, F, Ruggeri, A, Suzuki, R, Rafii, H, Kimura, F, Cappelli, B, Kondo, E, Scigliuolo, GM, Takahashi, S, Kenzey, C, Rivera-Franco, MM, Okamoto, S, Rocha, V, Chevallier, P, Sanz, J, Fürst, S, Cornelissen, J, Milpied, N, Uchida, N, Sugio, Y, Kimura, T, Ichinohe, T, Fukuda, T, Mohty, M, de Latour, RP, Atsuta, Y & Gluckman, E 2024, 'Cord blood transplantation for adult mature lymphoid neoplasms in Europe and Japan', Blood Advances, vol. 8, no. 3, pp. 640-552. https://doi.org/10.1182/bloodadvances.2023010598

TY - JOUR

T1 - Cord blood transplantation for adult mature lymphoid neoplasms in Europe and Japan

AU - Watanabe, Mizuki

AU - Kanda, Junya

AU - Volt, Fernanda

AU - Ruggeri, Annalisa

AU - Suzuki, Ritsuro

AU - Rafii, Hanadi

AU - Kimura, Fumihiko

AU - Cappelli, Barbara

AU - Kondo, Eisei

AU - Scigliuolo, Graziana Maria

AU - Takahashi, Satoshi

AU - Kenzey, Chantal

AU - Rivera-Franco, Monica M.

AU - Okamoto, Shinichiro

AU - Rocha, Vanderson

AU - Chevallier, Patrice

AU - Sanz, Jaime

AU - Fürst, Sabine

AU - Cornelissen, Jan

AU - Milpied, Noel

AU - Uchida, Naoyuki

AU - Sugio, Yasuhiro

AU - Kimura, Takafumi

AU - Ichinohe, Tatsuo

AU - Fukuda, Takahiro

AU - Mohty, Mohamad

AU - de Latour, Régis Peffault

AU - Atsuta, Yoshiko

AU - Gluckman, Eliane

PY - 2024/2/13

Y1 - 2024/2/13

N2 - To clarify the different characteristics and prognostic factors of cord blood transplantation (CBT) in adult patients with lymphoid neoplasms in Europe and Japan, we conducted a collaborative study. Patients aged 18-75 years receiving their first CBT (Europe: single CBT, n = 192; double CBT, n = 304; Japan: single CBT, n = 1150) in 2000-2017 were analyzed. Fewer patients with Hodgkin lymphoma (Europe vs Japan, 26% vs 5%), and older patients (≥50 years) (39% vs 59%) with a higher refined disease risk index (rDRI) (high-very high: 49% vs 14%) were included in the Japanese registry. High-very high rDRI was associated with inferior overall survival (OS) (vs low rDRI, Europe: hazard ratio [HR], 1.87; P = .001; Japan: HR, 2.34; P < .001) with higher progression/relapse risks. Total body irradiation (TBI)–containing conditioning contributed to superior OS both in Europe (vs TBI–reduced-intensity conditioning [RIC], non-TBI-RIC: HR, 1.93; P < .001; non-TBI–Myeloablative conditioning [MAC]: HR, 1.90; P = .003) and Japan (non–TBI-RIC: HR, 1.71; P < .001; non–TBI-MAC: HR 1.50, P = .007). The impact of HLA mismatches (≥2) on OS differed (Europe: HR, 1.52; P = .007; Japan: HR, 1.18; P = .107). CBT for lymphoid neoplasms, especially in those with high rDRI showed poor outcomes despite all the different characteristics in both registries. TBI should be considered in conditioning regimens to improve these outcomes. The different impacts of HLA mismatches call attention to the fundamental differences among these populations.

AB - To clarify the different characteristics and prognostic factors of cord blood transplantation (CBT) in adult patients with lymphoid neoplasms in Europe and Japan, we conducted a collaborative study. Patients aged 18-75 years receiving their first CBT (Europe: single CBT, n = 192; double CBT, n = 304; Japan: single CBT, n = 1150) in 2000-2017 were analyzed. Fewer patients with Hodgkin lymphoma (Europe vs Japan, 26% vs 5%), and older patients (≥50 years) (39% vs 59%) with a higher refined disease risk index (rDRI) (high-very high: 49% vs 14%) were included in the Japanese registry. High-very high rDRI was associated with inferior overall survival (OS) (vs low rDRI, Europe: hazard ratio [HR], 1.87; P = .001; Japan: HR, 2.34; P < .001) with higher progression/relapse risks. Total body irradiation (TBI)–containing conditioning contributed to superior OS both in Europe (vs TBI–reduced-intensity conditioning [RIC], non-TBI-RIC: HR, 1.93; P < .001; non-TBI–Myeloablative conditioning [MAC]: HR, 1.90; P = .003) and Japan (non–TBI-RIC: HR, 1.71; P < .001; non–TBI-MAC: HR 1.50, P = .007). The impact of HLA mismatches (≥2) on OS differed (Europe: HR, 1.52; P = .007; Japan: HR, 1.18; P = .107). CBT for lymphoid neoplasms, especially in those with high rDRI showed poor outcomes despite all the different characteristics in both registries. TBI should be considered in conditioning regimens to improve these outcomes. The different impacts of HLA mismatches call attention to the fundamental differences among these populations.

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SN - 2473-9529

VL - 8

SP - 640

EP - 552

JO - Blood Advances

JF - Blood Advances

IS - 3

ER -

Cord blood transplantation for adult mature lymphoid neoplasms in Europe and Japan

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