TY - JOUR
T1 - Core–shell inorganic NP@MOF nanostructures for targeted drug delivery and multimodal imaging-guided combination tumor treatment
AU - Khan, Suliman
AU - Falahati, Mojtaba
AU - Cho, William C.
AU - Vahdani, Yasaman
AU - Siddique, Rabeea
AU - Sharifi, Majid
AU - Jaragh-Alhadad, Laila Abdulmohsen
AU - Haghighat, Setareh
AU - Zhang, Xiaoju
AU - ten Hagen, Timo L.M.
AU - Bai, Qian
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023/11
Y1 - 2023/11
N2 - It is well known that metal–organic framework (MOF) nanostructures have unique characteristics such as high porosity, large surface areas and adjustable functionalities, so they are ideal candidates for developing drug delivery systems (DDSs) as well as theranostic platforms in cancer treatment. Despite the large number of MOF nanostructures that have been discovered, conventional MOF-derived nanosystems only have a single biofunctional MOF source with poor colloidal stability. Accordingly, developing core–shell MOF nanostructures with good colloidal stability is a useful method for generating efficient drug delivery, multimodal imaging and synergistic therapeutic systems. The preparation of core–shell MOF nanostructures has been done with a variety of materials, but inorganic nanoparticles (NPs) are highly effective for drug delivery and imaging-guided tumor treatment. Herein, we aimed to overview the synthesis of core–shell inorganic NP@MOF nanostructures followed by the application of core–shell MOFs derived from magnetic, quantum dots (QDs), gold (Au), and gadolinium (Gd) NPs in drug delivery and imaging-guided tumor treatment. Afterward, we surveyed different factors affecting prolonged drug delivery and cancer therapy, cellular uptake, biocompatibility, biodegradability, and enhanced permeation and retention (EPR) effect of core–shell MOFs. Last but not least, we discussed the challenges and the prospects of the field. We envision this article may hold great promise in providing valuable insights regarding the application of hybrid nanostructures as promising and potential candidates for multimodal imaging-guided combination cancer therapy.
AB - It is well known that metal–organic framework (MOF) nanostructures have unique characteristics such as high porosity, large surface areas and adjustable functionalities, so they are ideal candidates for developing drug delivery systems (DDSs) as well as theranostic platforms in cancer treatment. Despite the large number of MOF nanostructures that have been discovered, conventional MOF-derived nanosystems only have a single biofunctional MOF source with poor colloidal stability. Accordingly, developing core–shell MOF nanostructures with good colloidal stability is a useful method for generating efficient drug delivery, multimodal imaging and synergistic therapeutic systems. The preparation of core–shell MOF nanostructures has been done with a variety of materials, but inorganic nanoparticles (NPs) are highly effective for drug delivery and imaging-guided tumor treatment. Herein, we aimed to overview the synthesis of core–shell inorganic NP@MOF nanostructures followed by the application of core–shell MOFs derived from magnetic, quantum dots (QDs), gold (Au), and gadolinium (Gd) NPs in drug delivery and imaging-guided tumor treatment. Afterward, we surveyed different factors affecting prolonged drug delivery and cancer therapy, cellular uptake, biocompatibility, biodegradability, and enhanced permeation and retention (EPR) effect of core–shell MOFs. Last but not least, we discussed the challenges and the prospects of the field. We envision this article may hold great promise in providing valuable insights regarding the application of hybrid nanostructures as promising and potential candidates for multimodal imaging-guided combination cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=85173144210&partnerID=8YFLogxK
U2 - 10.1016/j.cis.2023.103007
DO - 10.1016/j.cis.2023.103007
M3 - Review article
C2 - 37812992
AN - SCOPUS:85173144210
SN - 0001-8686
VL - 321
JO - Advances in Colloid and Interface Science
JF - Advances in Colloid and Interface Science
M1 - 103007
ER -