TY - JOUR
T1 - Coronary Artery Calcium Scores After Prophylactic Premenopausal Bilateral Salpingo-Oophorectomy
AU - Beekman, Maarten J.
AU - Terra, Lara
AU - Heemskerk-Gerritsen, Bernadette A.M.
AU - van der Aalst, Carlijn M.
AU - Roeters van Lennep, Jeanine E.
AU - van Beurden, Marc
AU - van Doorn, Helena C.
AU - de Hullu, Joanne A.
AU - van Dorst, Eleonora B.L.
AU - Mom, Constantijne H.
AU - Mourits, Marian J.E.
AU - Slangen, Brigitte F.M.
AU - Bartels-Rutten, Annemarieke
AU - Budde, Ricardo P.J.
AU - Snoeren, Miranda M.
AU - Leiner, Tim
AU - de Jong, Pim A.
AU - Vliegenthart, Rozemarijn
AU - Planken, R. Nils
AU - Mihl, Casper
AU - Vonder, Marleen
AU - Oudkerk, Matthijs
AU - Gaarenstroom, Katja N.
AU - Gratama, Jan Willem C.
AU - van Engelen, Klaartje
AU - van der Kolk, Lizet E.
AU - Collée, J. Margriet
AU - Wevers, Marijke R.
AU - Ausems, Margreet G.E.M.
AU - Berger, Lieke P.V.
AU - Gomez Garcia, Encarna B.
AU - van Asperen, Christi J.
AU - Hooning, Maartje J.
AU - de Koning, Harry J.
AU - Maas, Angela H.E.M.
AU - van Leeuwen, Flora E.
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024/12
Y1 - 2024/12
N2 - Background: Premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at high familial risk of ovarian cancer leads to immediate menopause. Although early natural menopause is associated with increased cardiovascular disease risk, evidence on long-term cardiovascular disease risk after early surgical menopause is scarce. Objectives: We sought to determine the long-term influence of the timing of RRSO on the development of coronary artery calcium (CAC), an established marker for cardiovascular disease risk. Methods: We conducted a cross-sectional study (N = 733) nested in a nationwide cohort of women at high familial risk of ovarian cancer. In women aged 60-70 years (n = 328), we compared CAC scores between women with a premenopausal RRSO (age ≤45 years) and women with a postmenopausal RRSO (age ≥54 years), using multivariable Poisson analyses. Within the premenopausal RRSO group (n = 498), we also examined the effect of age at RRSO. In addition, we compared the premenopausal RRSO group with an external reference cohort (n = 5,226). Results: Multivariable analyses showed that the prevalence rates of any CAC (CAC >0), at least moderate CAC (CAC >100), and severe CAC (CAC >400) were comparable between the premenopausal and postmenopausal RRSO groups (relative risk [RR]: 0.93; 95% CI: 0.75-1.15 for any CAC; RR: 0.71; 95% CI: 0.43-1.17 for at least moderate CAC; RR: 0.81; 95% CI: 0.30-2.13 for severe CAC). There was no difference in CAC between the premenopausal RRSO group and a similar aged reference cohort. Timing of premenopausal RRSO (early premenopausal RRSO [<41 years] vs late premenopausal RRSO [41-45 years]) did not affect the outcomes. Conclusions: Our results do not show a long-term adverse effect of surgical menopause on the development of CAC.
AB - Background: Premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at high familial risk of ovarian cancer leads to immediate menopause. Although early natural menopause is associated with increased cardiovascular disease risk, evidence on long-term cardiovascular disease risk after early surgical menopause is scarce. Objectives: We sought to determine the long-term influence of the timing of RRSO on the development of coronary artery calcium (CAC), an established marker for cardiovascular disease risk. Methods: We conducted a cross-sectional study (N = 733) nested in a nationwide cohort of women at high familial risk of ovarian cancer. In women aged 60-70 years (n = 328), we compared CAC scores between women with a premenopausal RRSO (age ≤45 years) and women with a postmenopausal RRSO (age ≥54 years), using multivariable Poisson analyses. Within the premenopausal RRSO group (n = 498), we also examined the effect of age at RRSO. In addition, we compared the premenopausal RRSO group with an external reference cohort (n = 5,226). Results: Multivariable analyses showed that the prevalence rates of any CAC (CAC >0), at least moderate CAC (CAC >100), and severe CAC (CAC >400) were comparable between the premenopausal and postmenopausal RRSO groups (relative risk [RR]: 0.93; 95% CI: 0.75-1.15 for any CAC; RR: 0.71; 95% CI: 0.43-1.17 for at least moderate CAC; RR: 0.81; 95% CI: 0.30-2.13 for severe CAC). There was no difference in CAC between the premenopausal RRSO group and a similar aged reference cohort. Timing of premenopausal RRSO (early premenopausal RRSO [<41 years] vs late premenopausal RRSO [41-45 years]) did not affect the outcomes. Conclusions: Our results do not show a long-term adverse effect of surgical menopause on the development of CAC.
UR - http://www.scopus.com/inward/record.url?scp=85211016541&partnerID=8YFLogxK
U2 - 10.1016/j.jaccao.2024.09.011
DO - 10.1016/j.jaccao.2024.09.011
M3 - Article
C2 - 39801648
AN - SCOPUS:85211016541
SN - 2666-0873
VL - 6
SP - 922
EP - 931
JO - JACC: CardioOncology
JF - JACC: CardioOncology
IS - 6
ER -
