TY - JOUR
T1 - Coronary microvascular dysfunction
T2 - Focus on pathophysiological mechanisms and recent diagnostic techniques
AU - Mincione, Gianluca
AU - Maurina, Matteo
AU - Benedetti, Alice
AU - Chiarito, Mauro
AU - Stefanini, Giulio G.
AU - Smits, Pieter C.
AU - Paradies, Valeria
N1 - Publisher Copyright:
© 2025 Elsevier Inc.
PY - 2025/7
Y1 - 2025/7
N2 - In interventional cardiology, our efforts have traditionally centered on treating lesions in the epicardial coronary arteries, which can be visualized on coronary angiography. However, a significant proportion of patients experience similar symptoms to those with epicardial coronary artery lesions, yet without any angiographically visible coronary artery disease. These cases fall under the spectrum of coronary microvascular dysfunction. In this review, we will explore the disease's pathophysiology and focus on new frontiers in terms of diagnostic approaches and therapeutic strategies according to different endotypes.
AB - In interventional cardiology, our efforts have traditionally centered on treating lesions in the epicardial coronary arteries, which can be visualized on coronary angiography. However, a significant proportion of patients experience similar symptoms to those with epicardial coronary artery lesions, yet without any angiographically visible coronary artery disease. These cases fall under the spectrum of coronary microvascular dysfunction. In this review, we will explore the disease's pathophysiology and focus on new frontiers in terms of diagnostic approaches and therapeutic strategies according to different endotypes.
UR - https://www.scopus.com/pages/publications/105008895297
U2 - 10.1016/j.carrev.2025.06.015
DO - 10.1016/j.carrev.2025.06.015
M3 - Review article
C2 - 40562608
AN - SCOPUS:105008895297
SN - 1553-8389
VL - 76
SP - 25
EP - 29
JO - Cardiovascular Revascularization Medicine
JF - Cardiovascular Revascularization Medicine
ER -