Coronary revascularization in diabetic patients A focus on the 3-year SYNTAX trial outcomes

Mart Groot, Stuart Head, Ad Bogers, Arie-Pieter Kappetein

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)


The prevalence of diabetes is growing worldwide. Diabetics are predisposed to coronary artery disease due to an increased rate of atherosclerosis. The optimal treatment for these patients remains uncertain. Randomized trials compared percutaneous coronary intervention (PCI) to coronary artery bypass surgery (CABG) to determine the most suitable revascularization strategy. Meta-analyses suggest a survival advantage in favor of surgery over angioplasty or stenting with bare-metal stents (BMS). New evidence was needed since advances in medical therapy, PCI technology, and surgical techniques have emerged. The Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) trial was the first to compare a drug-eluting stent to CABG and showed an increased rate of major adverse cardiac or cerebrovascular events after PCI. Results are mainly driven by the increased rates in patients with high lesion complexity; therefore, the current evidence suggests that diabetic patients with complex coronary disease have better outcomes with CABG.
Original languageUndefined/Unknown
Pages (from-to)281-286
Number of pages6
Issue number3
Publication statusPublished - 2012

Research programs

  • EMC COEUR-09

Cite this