Coronary stenting with polymer-coated and uncoated self-expanding endoprostheses in pigs

Willem J. van der Giessen*, Heleen M.M. van Beusekom, Catharina D. van Houten, Leon J. van Woerkens, Pieter D. Verdouw, Patrick W. Serruys

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)


Background: Preliminary clinical reports suggest that metallic stents are thrombogenic during the first days to weeks after implantation but that restenosis rates after this period may be reduced. Methods: We investigated the angiographic patency and histologically measured neointimal hyperplasia of 48 uncoated self-expanding, stainless steel mesh stents (Wallstent, Schneider [Europe] AG, Bulach, Switzerland) placed in normal coronary arteries of three groups of eight pigs that received postprocedure aspirin (ASA, group B), acenocoumarol (group C), or no medication (group A). The results were compared with those obtained in a fourth group of eight pigs (group D) receiving 15 polymer-coated (BioGold, PlasmaCarb Inc., Bedford, NH, USA) Wallstent stents, which are designed to reduce thrombogenicity without additional medication. After 1, 4, and 12 weeks, angiography was repeated. After the last angiogram the coronary arteries were pressure-fixated followed by light microscopy, immunocytochemistry, and electron microscopic examination. Results: Group A showed a 38% thrombotic occlusion rate within 1 week, which was prevented by acenocoumarol or polymer coating, but not by ASA. Histologic analysis showed no difference in the thickness of neointimal hyperplasia between the groups (median values: 134, 101, 143 and 113 μm for groups A, B, C, and D, respectively). Polymer coating did not induce an inflammatory reaction. Conclusions: Acenocoumarol and the polymer coating protected against early thrombotic occlusion of stainless steel self- expanding stents, but neointimal hyperplasia was not affected by preventive measures against stent thrombosis.

Original languageEnglish
Pages (from-to)631-640
Number of pages10
JournalCoronary Artery Disease
Issue number7
Publication statusPublished - Jul 1992

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