Correlation between Histopathological Prognostic Tumor Characteristics and [18F]FDG Uptake in Corresponding Metastases in Newly Diagnosed Metastatic Breast Cancer

Jorianne Boers; Bertha Eisses; Mieke C. Zwager; Jasper J.L. van Geel; Frederike Bensch; Erik F.J. de Vries; Geke A.P. Hospers; Andor W.J.M. Glaudemans; Adrienne H. Brouwers; Martijn A.M. den Dekker; Sjoerd G. Elias; Evelien J.M. Kuip; Carla M.L. van Herpen; Agnes Jager; Astrid A.M. van der Veldt; Daniela E. Oprea-Lager; Elisabeth G.E. de Vries; Bert van der Vegt; Willemien C. Menke-van der Houven van Oordt; Carolina P. Schröder; on behalf of the IMPACT-Metastatic Breast Consortium

doi:10.3390/diagnostics14040416

Correlation between Histopathological Prognostic Tumor Characteristics and [¹⁸F]FDG Uptake in Corresponding Metastases in Newly Diagnosed Metastatic Breast Cancer

Jorianne Boers
, Bertha Eisses
, Mieke C. Zwager
, Jasper J.L. van Geel
, Frederike Bensch
, Erik F.J. de Vries
, Geke A.P. Hospers
, Andor W.J.M. Glaudemans
, Adrienne H. Brouwers
, Martijn A.M. den Dekker
, Sjoerd G. Elias
, Evelien J.M. Kuip
, Carla M.L. van Herpen
, Agnes Jager
, Astrid A.M. van der Veldt
, Daniela E. Oprea-Lager
, Elisabeth G.E. de Vries
, Bert van der Vegt
, Willemien C. Menke-van der Houven van Oordt
, Carolina P. Schröder^*

on behalf of the IMPACT-Metastatic Breast Consortium

^*Corresponding author for this work

Medical Oncology

Department of Medical Oncology
Netherlands Cancer Institute
Department of Medical Oncology
University Medical Centre Groningen
Utrecht University
Radboud University Medical Center
Amsterdam UMC

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

53 Downloads (Pure)

Abstract

Background:

In metastatic breast cancer (MBC), [¹⁸F]fluorodeoxyglucose positron emission tomography/computed tomography ([¹⁸F]FDG-PET/CT) can be used for staging. We evaluated the correlation between BC histopathological characteristics and [¹⁸F]FDG uptake in corresponding metastases.

Patients and Methods:

Patients with non-rapidly progressive MBC of all subtypes prospectively underwent a baseline histological metastasis biopsy and [¹⁸F]FDG-PET. Biopsies were assessed for estrogen, progesterone, and human epidermal growth factor receptor 2 (ER, PR, HER2); Ki-67; and histological subtype. [¹⁸F]FDG uptake was expressed as maximum standardized uptake value (SUV_max) and results were expressed as geometric means.

Results:

Of 200 patients, 188 had evaluable metastasis biopsies, and 182 of these contained tumor. HER2 positivity and Ki-67 ≥ 20% were correlated with higher [¹⁸F]FDG uptake (estimated geometric mean SUV_max 10.0 and 8.8, respectively; p = 0.0064 and p = 0.014). [¹⁸F]FDG uptake was lowest in ER-positive/HER2-negative BC and highest in HER2-positive BC (geometric mean SUV_max 6.8 and 10.0, respectively; p = 0.0058). Although [¹⁸F]FDG uptake was lower in invasive lobular carcinoma (n = 31) than invasive carcinoma NST (n = 146) (estimated geometric mean SUV_max 5.8 versus 7.8; p = 0.014), the metastasis detection rate was similar.

Conclusions:

[¹⁸F]FDG-PET is a powerful tool to detect metastases, including invasive lobular carcinoma. Although BC histopathological characteristics are related to [¹⁸F]FDG uptake, [¹⁸F]FDG-PET and biopsy remain complementary in MBC staging (NCT01957332).

Original language	English
Article number	416
Number of pages	14
Journal	Diagnostics
Volume	14
Issue number	4
DOIs	https://doi.org/10.3390/diagnostics14040416
Publication status	Published - 14 Feb 2024

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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diagnostics-14-00416-v3Final published version, 3.8 MBLicence: CC BY

Cite this

Boers, J., Eisses, B., Zwager, M. C., van Geel, J. J. L., Bensch, F., de Vries, E. F. J., Hospers, G. A. P., Glaudemans, A. W. J. M., Brouwers, A. H., den Dekker, M. A. M., Elias, S. G., Kuip, E. J. M., van Herpen, C. M. L., Jager, A., van der Veldt, A. A. M., Oprea-Lager, D. E., de Vries, E. G. E., van der Vegt, B., Menke-van der Houven van Oordt, W. C., ... on behalf of the IMPACT-Metastatic Breast Consortium (2024). Correlation between Histopathological Prognostic Tumor Characteristics and [¹⁸F]FDG Uptake in Corresponding Metastases in Newly Diagnosed Metastatic Breast Cancer. Diagnostics, 14(4), Article 416. https://doi.org/10.3390/diagnostics14040416

@article{9b752db0e67f46a3a2f1c0ee4a80ec92,

title = "Correlation between Histopathological Prognostic Tumor Characteristics and [18F]FDG Uptake in Corresponding Metastases in Newly Diagnosed Metastatic Breast Cancer",

abstract = "Background: In metastatic breast cancer (MBC), [18F]fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) can be used for staging. We evaluated the correlation between BC histopathological characteristics and [18F]FDG uptake in corresponding metastases. Patients and Methods: Patients with non-rapidly progressive MBC of all subtypes prospectively underwent a baseline histological metastasis biopsy and [18F]FDG-PET. Biopsies were assessed for estrogen, progesterone, and human epidermal growth factor receptor 2 (ER, PR, HER2); Ki-67; and histological subtype. [18F]FDG uptake was expressed as maximum standardized uptake value (SUVmax) and results were expressed as geometric means. Results: Of 200 patients, 188 had evaluable metastasis biopsies, and 182 of these contained tumor. HER2 positivity and Ki-67 ≥ 20\% were correlated with higher [18F]FDG uptake (estimated geometric mean SUVmax 10.0 and 8.8, respectively; p = 0.0064 and p = 0.014). [18F]FDG uptake was lowest in ER-positive/HER2-negative BC and highest in HER2-positive BC (geometric mean SUVmax 6.8 and 10.0, respectively; p = 0.0058). Although [18F]FDG uptake was lower in invasive lobular carcinoma (n = 31) than invasive carcinoma NST (n = 146) (estimated geometric mean SUVmax 5.8 versus 7.8; p = 0.014), the metastasis detection rate was similar. Conclusions:[18F]FDG-PET is a powerful tool to detect metastases, including invasive lobular carcinoma. Although BC histopathological characteristics are related to [18F]FDG uptake, [18F]FDG-PET and biopsy remain complementary in MBC staging (NCT01957332).",

author = "Jorianne Boers and Bertha Eisses and Zwager, \{Mieke C.\} and \{van Geel\}, \{Jasper J.L.\} and Frederike Bensch and \{de Vries\}, \{Erik F.J.\} and Hospers, \{Geke A.P.\} and Glaudemans, \{Andor W.J.M.\} and Brouwers, \{Adrienne H.\} and \{den Dekker\}, \{Martijn A.M.\} and Elias, \{Sjoerd G.\} and Kuip, \{Evelien J.M.\} and \{van Herpen\}, \{Carla M.L.\} and Agnes Jager and \{van der Veldt\}, \{Astrid A.M.\} and Oprea-Lager, \{Daniela E.\} and \{de Vries\}, \{Elisabeth G.E.\} and \{van der Vegt\}, Bert and \{Menke-van der Houven van Oordt\}, \{Willemien C.\} and Schr{\"o}der, \{Carolina P.\} and \{on behalf of the IMPACT-Metastatic Breast Consortium\}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = feb,

day = "14",

doi = "10.3390/diagnostics14040416",

language = "English",

volume = "14",

journal = "Diagnostics",

issn = "2075-4418",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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Boers, J, Eisses, B, Zwager, MC, van Geel, JJL, Bensch, F, de Vries, EFJ, Hospers, GAP, Glaudemans, AWJM, Brouwers, AH, den Dekker, MAM, Elias, SG, Kuip, EJM, van Herpen, CML, Jager, A , van der Veldt, AAM, Oprea-Lager, DE, de Vries, EGE, van der Vegt, B, Menke-van der Houven van Oordt, WC, Schröder, CP & on behalf of the IMPACT-Metastatic Breast Consortium 2024, 'Correlation between Histopathological Prognostic Tumor Characteristics and [¹⁸F]FDG Uptake in Corresponding Metastases in Newly Diagnosed Metastatic Breast Cancer', Diagnostics, vol. 14, no. 4, 416. https://doi.org/10.3390/diagnostics14040416

TY - JOUR

T1 - Correlation between Histopathological Prognostic Tumor Characteristics and [18F]FDG Uptake in Corresponding Metastases in Newly Diagnosed Metastatic Breast Cancer

AU - Boers, Jorianne

AU - Eisses, Bertha

AU - Zwager, Mieke C.

AU - van Geel, Jasper J.L.

AU - Bensch, Frederike

AU - de Vries, Erik F.J.

AU - Hospers, Geke A.P.

AU - Glaudemans, Andor W.J.M.

AU - Brouwers, Adrienne H.

AU - den Dekker, Martijn A.M.

AU - Elias, Sjoerd G.

AU - Kuip, Evelien J.M.

AU - van Herpen, Carla M.L.

AU - Jager, Agnes

AU - van der Veldt, Astrid A.M.

AU - Oprea-Lager, Daniela E.

AU - de Vries, Elisabeth G.E.

AU - van der Vegt, Bert

AU - Menke-van der Houven van Oordt, Willemien C.

AU - Schröder, Carolina P.

AU - on behalf of the IMPACT-Metastatic Breast Consortium

PY - 2024/2/14

Y1 - 2024/2/14

N2 - Background: In metastatic breast cancer (MBC), [18F]fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) can be used for staging. We evaluated the correlation between BC histopathological characteristics and [18F]FDG uptake in corresponding metastases. Patients and Methods: Patients with non-rapidly progressive MBC of all subtypes prospectively underwent a baseline histological metastasis biopsy and [18F]FDG-PET. Biopsies were assessed for estrogen, progesterone, and human epidermal growth factor receptor 2 (ER, PR, HER2); Ki-67; and histological subtype. [18F]FDG uptake was expressed as maximum standardized uptake value (SUVmax) and results were expressed as geometric means. Results: Of 200 patients, 188 had evaluable metastasis biopsies, and 182 of these contained tumor. HER2 positivity and Ki-67 ≥ 20% were correlated with higher [18F]FDG uptake (estimated geometric mean SUVmax 10.0 and 8.8, respectively; p = 0.0064 and p = 0.014). [18F]FDG uptake was lowest in ER-positive/HER2-negative BC and highest in HER2-positive BC (geometric mean SUVmax 6.8 and 10.0, respectively; p = 0.0058). Although [18F]FDG uptake was lower in invasive lobular carcinoma (n = 31) than invasive carcinoma NST (n = 146) (estimated geometric mean SUVmax 5.8 versus 7.8; p = 0.014), the metastasis detection rate was similar. Conclusions:[18F]FDG-PET is a powerful tool to detect metastases, including invasive lobular carcinoma. Although BC histopathological characteristics are related to [18F]FDG uptake, [18F]FDG-PET and biopsy remain complementary in MBC staging (NCT01957332).

AB - Background: In metastatic breast cancer (MBC), [18F]fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) can be used for staging. We evaluated the correlation between BC histopathological characteristics and [18F]FDG uptake in corresponding metastases. Patients and Methods: Patients with non-rapidly progressive MBC of all subtypes prospectively underwent a baseline histological metastasis biopsy and [18F]FDG-PET. Biopsies were assessed for estrogen, progesterone, and human epidermal growth factor receptor 2 (ER, PR, HER2); Ki-67; and histological subtype. [18F]FDG uptake was expressed as maximum standardized uptake value (SUVmax) and results were expressed as geometric means. Results: Of 200 patients, 188 had evaluable metastasis biopsies, and 182 of these contained tumor. HER2 positivity and Ki-67 ≥ 20% were correlated with higher [18F]FDG uptake (estimated geometric mean SUVmax 10.0 and 8.8, respectively; p = 0.0064 and p = 0.014). [18F]FDG uptake was lowest in ER-positive/HER2-negative BC and highest in HER2-positive BC (geometric mean SUVmax 6.8 and 10.0, respectively; p = 0.0058). Although [18F]FDG uptake was lower in invasive lobular carcinoma (n = 31) than invasive carcinoma NST (n = 146) (estimated geometric mean SUVmax 5.8 versus 7.8; p = 0.014), the metastasis detection rate was similar. Conclusions:[18F]FDG-PET is a powerful tool to detect metastases, including invasive lobular carcinoma. Although BC histopathological characteristics are related to [18F]FDG uptake, [18F]FDG-PET and biopsy remain complementary in MBC staging (NCT01957332).

UR - https://www.scopus.com/pages/publications/85185955771

U2 - 10.3390/diagnostics14040416

DO - 10.3390/diagnostics14040416

M3 - Article

C2 - 38396455

AN - SCOPUS:85185955771

SN - 2075-4418

VL - 14

JO - Diagnostics

JF - Diagnostics

IS - 4

M1 - 416

ER -