Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients

Susanne J. Van Veluw; Saima Hilal; Hugo J. Kuijf; Mohammad Kamran Ikram; Xu Xin; Tan Boon Yeow; Narayanaswamy Venketasubramanian; Geert Jan Biessels; Christopher Chen

doi:10.1016/j.jalz.2014.12.010

Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients

Susanne J. Van Veluw^*, Saima Hilal, Hugo J. Kuijf, Mohammad Kamran Ikram, Xu Xin, Tan Boon Yeow, Narayanaswamy Venketasubramanian, Geert Jan Biessels, Christopher Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Introduction This is the first study to assess cerebral microinfarcts (CMIs) on 3 tesla (3T) magnetic resonance imaging (MRI) in a memory clinic population. Methods We included 238 consecutive patients (aged 72.5 ± 9.1 years) from a memory clinic in Singapore. All patients underwent extensive neurological and neuropsychological testing and 3T MRI on the same day. Cortical CMI rating criteria were adapted from a previous study on 7T MRI. We analyzed the frequency and association of cortical CMIs with demographic, clinical, cognition, and other MRI findings. Results Seventy-five patients (32%) had cortical CMIs (median 1, range 1-43). Patients with CMIs showed worse cognitive functioning on MMSE, and in the domains of language and visuoconstruction. The presence of CMIs was related to other markers of small vessel disease, but most strongly larger cortical infarcts. Patients with CMIs were more often diagnosed with vascular dementia. Discussion Cortical CMIs on 3T MRI are a novel marker of cerebrovascular disease in dementia.

Original language	English
Pages (from-to)	1500-1509
Number of pages	10
Journal	Alzheimer's and Dementia
Volume	11
Issue number	12
DOIs	https://doi.org/10.1016/j.jalz.2014.12.010
Publication status	Published - Dec 2015
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by an Alzheimer Nederland fellowship to SJvV [WE 15-2013-07], a VIDI grant from ZonMw , The Netherlands Organization for Health Research and Development [ 91711384 ], and a clinical established investigator grant from the Netherlands Heart Foundation [ 2010 T073 ] to GJB, and by the Singapore National Medical Research Council center grants [ NMRC/NUHCS/2010 ] and [ NMRC/NUHS/2010 ] [ R-184-006-184-511 ] to CC. MKI received additional funding from the Singapore Ministry of Health's National Medical Research Council [ NMRC/CSA/038/2013 ].

Publisher Copyright:
© 2015 The Alzheimer's Association.

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10.1016/j.jalz.2014.12.010

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title = "Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients",

abstract = "Introduction This is the first study to assess cerebral microinfarcts (CMIs) on 3 tesla (3T) magnetic resonance imaging (MRI) in a memory clinic population. Methods We included 238 consecutive patients (aged 72.5 ± 9.1 years) from a memory clinic in Singapore. All patients underwent extensive neurological and neuropsychological testing and 3T MRI on the same day. Cortical CMI rating criteria were adapted from a previous study on 7T MRI. We analyzed the frequency and association of cortical CMIs with demographic, clinical, cognition, and other MRI findings. Results Seventy-five patients (32%) had cortical CMIs (median 1, range 1-43). Patients with CMIs showed worse cognitive functioning on MMSE, and in the domains of language and visuoconstruction. The presence of CMIs was related to other markers of small vessel disease, but most strongly larger cortical infarcts. Patients with CMIs were more often diagnosed with vascular dementia. Discussion Cortical CMIs on 3T MRI are a novel marker of cerebrovascular disease in dementia.",

author = "{Van Veluw}, {Susanne J.} and Saima Hilal and Kuijf, {Hugo J.} and Ikram, {Mohammad Kamran} and Xu Xin and Yeow, {Tan Boon} and Narayanaswamy Venketasubramanian and Biessels, {Geert Jan} and Christopher Chen",

note = "Funding Information: This work was supported by an Alzheimer Nederland fellowship to SJvV [WE 15-2013-07], a VIDI grant from ZonMw , The Netherlands Organization for Health Research and Development [ 91711384 ], and a clinical established investigator grant from the Netherlands Heart Foundation [ 2010 T073 ] to GJB, and by the Singapore National Medical Research Council center grants [ NMRC/NUHCS/2010 ] and [ NMRC/NUHS/2010 ] [ R-184-006-184-511 ] to CC. MKI received additional funding from the Singapore Ministry of Health's National Medical Research Council [ NMRC/CSA/038/2013 ]. Publisher Copyright: {\textcopyright} 2015 The Alzheimer's Association.",

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T1 - Cortical microinfarcts on 3T MRI

T2 - Clinical correlates in memory-clinic patients

AU - Van Veluw, Susanne J.

AU - Hilal, Saima

AU - Kuijf, Hugo J.

AU - Ikram, Mohammad Kamran

AU - Xin, Xu

AU - Yeow, Tan Boon

AU - Venketasubramanian, Narayanaswamy

AU - Biessels, Geert Jan

AU - Chen, Christopher

N1 - Funding Information: This work was supported by an Alzheimer Nederland fellowship to SJvV [WE 15-2013-07], a VIDI grant from ZonMw , The Netherlands Organization for Health Research and Development [ 91711384 ], and a clinical established investigator grant from the Netherlands Heart Foundation [ 2010 T073 ] to GJB, and by the Singapore National Medical Research Council center grants [ NMRC/NUHCS/2010 ] and [ NMRC/NUHS/2010 ] [ R-184-006-184-511 ] to CC. MKI received additional funding from the Singapore Ministry of Health's National Medical Research Council [ NMRC/CSA/038/2013 ]. Publisher Copyright: © 2015 The Alzheimer's Association.

PY - 2015/12

Y1 - 2015/12

N2 - Introduction This is the first study to assess cerebral microinfarcts (CMIs) on 3 tesla (3T) magnetic resonance imaging (MRI) in a memory clinic population. Methods We included 238 consecutive patients (aged 72.5 ± 9.1 years) from a memory clinic in Singapore. All patients underwent extensive neurological and neuropsychological testing and 3T MRI on the same day. Cortical CMI rating criteria were adapted from a previous study on 7T MRI. We analyzed the frequency and association of cortical CMIs with demographic, clinical, cognition, and other MRI findings. Results Seventy-five patients (32%) had cortical CMIs (median 1, range 1-43). Patients with CMIs showed worse cognitive functioning on MMSE, and in the domains of language and visuoconstruction. The presence of CMIs was related to other markers of small vessel disease, but most strongly larger cortical infarcts. Patients with CMIs were more often diagnosed with vascular dementia. Discussion Cortical CMIs on 3T MRI are a novel marker of cerebrovascular disease in dementia.

AB - Introduction This is the first study to assess cerebral microinfarcts (CMIs) on 3 tesla (3T) magnetic resonance imaging (MRI) in a memory clinic population. Methods We included 238 consecutive patients (aged 72.5 ± 9.1 years) from a memory clinic in Singapore. All patients underwent extensive neurological and neuropsychological testing and 3T MRI on the same day. Cortical CMI rating criteria were adapted from a previous study on 7T MRI. We analyzed the frequency and association of cortical CMIs with demographic, clinical, cognition, and other MRI findings. Results Seventy-five patients (32%) had cortical CMIs (median 1, range 1-43). Patients with CMIs showed worse cognitive functioning on MMSE, and in the domains of language and visuoconstruction. The presence of CMIs was related to other markers of small vessel disease, but most strongly larger cortical infarcts. Patients with CMIs were more often diagnosed with vascular dementia. Discussion Cortical CMIs on 3T MRI are a novel marker of cerebrovascular disease in dementia.

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Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients

Abstract

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