Cost analysis of the treatment of schizophrenia in the UK: A simulation model comparing olanzapine, risperidone and haloperidol

Stephen Almond*, Owen O'Donnell

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

62 Citations (Scopus)

Abstract

Objective: To compare the costs of 2 atypical drug therapies (olanzapine and risperidone) with one another and with a conventional antipsychotic (haloperidol) in the treatment of schizophrenia. Design and setting: The analysis is based on a simulation model with parameter values taken mainly from clinical trial data in patients with schizophrenia, and was conducted within a UK context. Results: The 3 therapies are approximately cost neutral over a 5-year period (olanzapine (L)35 701, risperidone (L)36 590 and haloperidol (L)36 653). There is evidence of greater efficacy with the atypical drugs [average percentage of 5 years with Brief Psychiatric Rating Scale (BPRS) scores <18: olanzapine 63.6%, risperidone 63.0% and haloperidol 52.2%]. The cost and efficacy differences between the 2 atypical drugs are too small to rank them in terms of cost effectiveness. Extensive sensitivity analysis does not change any of the main conclusions. Conclusions: Given evidence of efficacy gains to the atypical drugs, these represent cost- effective treatment options. Prospective data from nontrial treatment settings would help substantiate the model findings.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalPharmacoEconomics
Volume17
Issue number4
DOIs
Publication statusPublished - 2000

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