Cost-effectiveness models for Alzheimer's disease and related dementias: IPECAD modeling workshop cross-comparison challenge

Ron L H Handels, Colin Green, Anders Gustavsson, William L Herring, Bengt Winblad, Anders Wimo, Anders Sköldunger, Andreas Karlsson, Robert Anderson, Mark Belger, Chiara Brück, Robert Espinosa, Jakub P Hlávka, Eric Jutkowitz, Pei-Jung Lin, Mauricio Lopez Mendez, Javier Mar, Peter Shewmaker, Eldon Spackman, Ali TafazzoliBryan Tysinger, Linus Jönsson, IPECAD modeling workshop 2020 participants

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INTRODUCTION: The credibility of model-based economic evaluations of Alzheimer's disease (AD) interventions is central to appropriate decision-making in a policy context. We report on the International PharmacoEconomic Collaboration on Alzheimer's Disease (IPECAD) Modeling Workshop Challenge.

METHODS: Two common benchmark scenarios, for the hypothetical treatment of AD mild cognitive impairment (MCI) and mild dementia, were developed jointly by 29 participants. Model outcomes were summarized, and cross-comparisons were discussed during a structured workshop.

RESULTS: A broad concordance was established among participants. Mean 10-year restricted survival and time in MCI in the control group ranged across 10 MCI models from 6.7 to 9.5 years and 3.4 to 5.6 years, respectively; and across 4 mild dementia models from 5.4 to 7.9 years (survival) and 1.5 to 4.2 years (mild dementia).

DISCUSSION: The model comparison increased our understanding of methods, data used, and disease progression. We established a collaboration framework to assess cost-effectiveness outcomes, an important step toward transparent and credible AD models.

Original languageEnglish
JournalAlzheimer's & dementia : the journal of the Alzheimer's Association
Publication statusE-pub ahead of print - 25 Oct 2022

Bibliographical note

© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.


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