Costs, effects and C/E‐ratios alongside a clinical trial

Ben A. Van Hout*, Maiwenn J. Al, Gilad S. Gordon, Frans F.H. Rutten

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

791 Citations (Scopus)


A general approach is discussed to assess the uncertainty surrounding the cost effectiveness ratio (C/E‐ratio) estimated on the basis of data from a randomised clinical trial. The approach includes the calculation of a 95% probability ellipse and introduces the concept of a so called C/E‐acceptability curve. This last curve defines for each predefined C/E‐ratio the probability that the C/E‐ratio found in the study is acceptable. The approach is illustrated by estimates of costs per life saved and costs per patient discharged alive on the basis of data from a phase II trial addressing the value of anakinra in treating sepsis syndrome.

Original languageEnglish
Pages (from-to)309-319
Number of pages11
JournalHealth Economics
Issue number5
Publication statusPublished - Sept 1994


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