COVID-19-related myocarditis post-heart transplantation

Stefan Roest; Jasper J. Brugts; Jeroen J.A. van Kampen; Jan H. von der Thüsen; Alina A. Constantinescu; Kadir Caliskan; Alexander Hirsch; Olivier C. Manintveld

doi:10.1016/j.ijid.2021.04.013

COVID-19-related myocarditis post-heart transplantation

Stefan Roest, Jasper J. Brugts, Jeroen J.A. van Kampen, Jan H. von der Thüsen, Alina A. Constantinescu, Kadir Caliskan, Alexander Hirsch, Olivier C. Manintveld^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

This report describes the first heart transplantation recipient with acute biventricular heart failure symptoms caused by a post-myocarditis state, late after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. No other viral pathogens could be detected. Computed tomography angiography did not show cardiac allograft vasculopathy, and myocardial biopsy demonstrated no clinically relevant rejection. Subsequent cardiovascular magnetic resonance imaging revealed extensive epicardial delayed enhancement without myocardial edema. Heart failure medication was initiated and an implantable cardioverter defibrillator was implanted (due to non-sustained ventricular tachycardias), leading to a partial recovery of the ejection fraction. Further studies are needed to investigate the number of heart transplant recipients with myocardial damage after a SARS-CoV-2 infection.

Original language	English
Pages (from-to)	34-36
Number of pages	3
Journal	International Journal of Infectious Diseases
Volume	107
Early online date	13 Apr 2021
DOIs	https://doi.org/10.1016/j.ijid.2021.04.013
Publication status	Published - 1 Jun 2021

Bibliographical note

Funding Information:
JJB declares a grant from Abbott outside the scope of this work. All other authors have no conflicts of interest to disclose.

Publisher Copyright:
© 2021 The Author(s)

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COVID-19-related myocarditis post-heart transplantationFinal published version, 417 KBLicence: CC BY

Cite this

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title = "COVID-19-related myocarditis post-heart transplantation",

abstract = "This report describes the first heart transplantation recipient with acute biventricular heart failure symptoms caused by a post-myocarditis state, late after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. No other viral pathogens could be detected. Computed tomography angiography did not show cardiac allograft vasculopathy, and myocardial biopsy demonstrated no clinically relevant rejection. Subsequent cardiovascular magnetic resonance imaging revealed extensive epicardial delayed enhancement without myocardial edema. Heart failure medication was initiated and an implantable cardioverter defibrillator was implanted (due to non-sustained ventricular tachycardias), leading to a partial recovery of the ejection fraction. Further studies are needed to investigate the number of heart transplant recipients with myocardial damage after a SARS-CoV-2 infection.",

author = "Stefan Roest and Brugts, \{Jasper J.\} and \{van Kampen\}, \{Jeroen J.A.\} and \{von der Th{\"u}sen\}, \{Jan H.\} and Constantinescu, \{Alina A.\} and Kadir Caliskan and Alexander Hirsch and Manintveld, \{Olivier C.\}",

note = "Funding Information: JJB declares a grant from Abbott outside the scope of this work. All other authors have no conflicts of interest to disclose. Publisher Copyright: {\textcopyright} 2021 The Author(s)",

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doi = "10.1016/j.ijid.2021.04.013",

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AU - Roest, Stefan

AU - Brugts, Jasper J.

AU - van Kampen, Jeroen J.A.

AU - von der Thüsen, Jan H.

AU - Constantinescu, Alina A.

AU - Caliskan, Kadir

AU - Hirsch, Alexander

AU - Manintveld, Olivier C.

PY - 2021/6/1

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AB - This report describes the first heart transplantation recipient with acute biventricular heart failure symptoms caused by a post-myocarditis state, late after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. No other viral pathogens could be detected. Computed tomography angiography did not show cardiac allograft vasculopathy, and myocardial biopsy demonstrated no clinically relevant rejection. Subsequent cardiovascular magnetic resonance imaging revealed extensive epicardial delayed enhancement without myocardial edema. Heart failure medication was initiated and an implantable cardioverter defibrillator was implanted (due to non-sustained ventricular tachycardias), leading to a partial recovery of the ejection fraction. Further studies are needed to investigate the number of heart transplant recipients with myocardial damage after a SARS-CoV-2 infection.

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COVID-19-related myocarditis post-heart transplantation

Abstract

Bibliographical note

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