Craniosynostosis: primary and secondary brain anomalies: A radiologic investigation

Nine de Planque

Craniosynostosis: primary and secondary brain anomalies: A radiologic investigation

Nine de Planque

Plastic and Reconstructive Surgery and Hand Surgery

Research output: Types of Thesis › Doctoral Thesis › Internal

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Abstract

This thesis shows the complexity of the course of patients with craniosynostosis. To answer the question if brain development in craniosynostosis is led by intrinsic brain abnormalities or the potential effect of ICH: the brain development is affected by both intrinsic genetic causes as well as the effect of ICH and its interconnected problems, such as hydrocephalus and tonsillar herniation. Further research is necessary to understand the clinical course and outcome in patients of non-syndromic craniosynostosis as well as the clinical course and outcome in patients with syndromic craniosynostosis. Finally, future studies should focus on to optimize the individual surgical treatment and to predict the clinical neurocognitive outcome.

Original language	English
Awarding Institution	Erasmus University Rotterdam
Supervisors/Advisors	Mathijssen, Irene, Supervisor van Veelen-Vincent, Marie L.C., Co-supervisor
Award date	12 Dec 2022
Place of Publication	Rotterdam
Print ISBNs	978-94-6458-727-2
Publication status	Published - 9 Dec 2022

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final dissertation Planque, Nine deFinal published version, 11.5 MB

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title = "Craniosynostosis: primary and secondary brain anomalies: A radiologic investigation",

abstract = "This thesis shows the complexity of the course of patients with craniosynostosis. To answer the question if brain development in craniosynostosis is led by intrinsic brain abnormalities or the potential effect of ICH: the brain development is affected by both intrinsic genetic causes as well as the effect of ICH and its interconnected problems, such as hydrocephalus and tonsillar herniation. Further research is necessary to understand the clinical course and outcome in patients of non-syndromic craniosynostosis as well as the clinical course and outcome in patients with syndromic craniosynostosis. Finally, future studies should focus on to optimize the individual surgical treatment and to predict the clinical neurocognitive outcome.",

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AB - This thesis shows the complexity of the course of patients with craniosynostosis. To answer the question if brain development in craniosynostosis is led by intrinsic brain abnormalities or the potential effect of ICH: the brain development is affected by both intrinsic genetic causes as well as the effect of ICH and its interconnected problems, such as hydrocephalus and tonsillar herniation. Further research is necessary to understand the clinical course and outcome in patients of non-syndromic craniosynostosis as well as the clinical course and outcome in patients with syndromic craniosynostosis. Finally, future studies should focus on to optimize the individual surgical treatment and to predict the clinical neurocognitive outcome.

M3 - Doctoral Thesis

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ER -

Craniosynostosis: primary and secondary brain anomalies: A radiologic investigation

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