Creatinaemia at birth is equal to maternal creatinaemia at delivery: Does this paradigm still hold

Maike Kuppens, Isabelle George, Liesbeth Lewi, Elena Levtchenko, Karel Allegaert*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)



The paradigm that creatinaemia at birth is equal to maternal creatinaemia may also depend upon the quantification technique applied. Paired maternal-neonatal creatinaemia samples in whom Jaffe in both or compensated Jaffe (maternal) and enzymatic quantification (neonate) were applied. 


Extreme low birth weight infants in two time intervals were included when paired maternal-neonatal creatinaemia samples were available. In cohort 1 (20002005), creatinaemia (mothers and neonates) was based on Jaffe assay. In cohort 2 (20072010), maternal creatinaemia was based on compensated Jaffe. In neonates, an enzymatic technique was applied. Unpaired Mann Whitney U, paired Wilcoxon and Bland-Altman were used. 


Based on 80 and 52 paired creatinaemia samples, there was no significant difference between maternal (0.80, 0.411.6mg.dl-1) and neonatal creatinaemia (0.78, 0.311.46mg.dl -1) in cohort 1 while a significant difference (p<0.001) between maternal (0.6, 0.292.24mg.dl-1) and neonatal creatinaemia (0.67, 0.42.2mg.dl-1) was observed for cohort 2. Using Bland-Altman, the fit was perfect for cohort 1 (mean diff -0.02mg.dl-1), but not for cohort 2 (-0.08mg.dl-1). 


The quantification method affects the paradigm that creatinaemia at birth is similar to maternal creatinaemia. Maternal and neonatal creatinaemia values depend on the method used. Consequently, method-specific reference values are needed.

Original languageEnglish
Pages (from-to)978-980
Number of pages3
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number7
Publication statusPublished - Jul 2012
Externally publishedYes

Bibliographical note

Funding Information:
Declaration of Interest: Elena Levtchenko and Karel Allegaert are supported by the Fund for Scientific Research, Flanders (Belgium) (F.W.O. Vlaanderen) by a Fundamental Clinical Investigatorship (1801110N and 1800209N).


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