Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women

Julianne Skarha; Lidia Mínguez-Alarcón; Paige L. Williams; Tim I.M. Korevaar; Ralph A. de Poortere; Maarten A.C. Broeren; Jennifer B. Ford; Melissa Eliot; Russ Hauser; Joseph M. Braun

doi:10.1016/j.envint.2018.11.015

Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women

Julianne Skarha
, Lidia Mínguez-Alarcón
, Paige L. Williams
, Tim I.M. Korevaar
, Ralph A. de Poortere
, Maarten A.C. Broeren
, Jennifer B. Ford
, Melissa Eliot
, Russ Hauser
, Joseph M. Braun^*

^*Corresponding author for this work

Internal Medicine

Brown University
Harvard T.H. Chan School of Public Health
Maxima Medical Centre

Research output: Contribution to journal › Article › Academic › peer-review

47 Citations (Scopus)

105 Downloads (Pure)

Abstract

Introduction: Exposure to the antimicrobial agent triclosan is ubiquitous. Research in animals shows that triclosan can cause decreases in thyroxine concentrations. However, the potential effects of triclosan on thyroid function in humans are unclear. Objective: To estimate the association between urinary triclosan concentrations and serum thyroid function biomarkers in women seeking assisted reproduction treatment in the Environment and Reproductive Health (EARTH) Study. Methods: We conducted a cross-sectional study of 317 women enrolled in the EARTH Study, a prospective preconception cohort that recruits Boston area couples. Using samples collected at study entry, we quantified urinary triclosan and serum thyroid function biomarker concentrations, specifically free and total thyroxine and triiodothyronine, thyroid-stimulating hormone (TSH), and thyroid antibodies. We estimated covariate-adjusted differences in thyroid function biomarkers per 10-fold increase in triclosan using linear regression models. We examined effect modification by body mass index (BMI) and infertility diagnosis. Results: The median urinary triclosan concentration was 7.8 μg/L (IQR: 3.0–59 μg/L). Each 10-fold increase in triclosan was inversely associated with free triidothyronine (T₃) (β: −0.06 pg/mL; 95% CI: −0.1, −0.01), thyroperoxidase antibody (TPOAb) (−10%; 95% CI: −19, −0.4), and thyroglobulin antibody (TgAb) (−12%; 95% CI: −23,0.9) concentrations. BMI and infertility diagnosis modified the association of triclosan with free T₃ and TPOAb, respectively. Conclusion: Urinary triclosan concentrations were inversely associated with specific serum thyroid function biomarkers in this cohort, suggesting that triclosan may affect thyroid homeostasis and autoimmunity.

Original language	English
Pages (from-to)	256-262
Number of pages	7
Journal	Environment international
Volume	122
DOIs	https://doi.org/10.1016/j.envint.2018.11.015
Publication status	Published - Jan 2019

Bibliographical note

Funding Information:
This work was supported by grants from the National Institute of Environmental Health Sciences ( R01 ES024381 and R01 ES027408 ).

Publisher Copyright:
© 2018 Elsevier Ltd

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Skarha, J., Mínguez-Alarcón, L., Williams, P. L., Korevaar, T. I. M., de Poortere, R. A., Broeren, M. A. C., Ford, J. B., Eliot, M., Hauser, R., & Braun, J. M. (2019). Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women. Environment international, 122, 256-262. https://doi.org/10.1016/j.envint.2018.11.015

@article{65a0b320c1484fd2a257f4fa1be9c3e8,

title = "Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women",

abstract = "Introduction: Exposure to the antimicrobial agent triclosan is ubiquitous. Research in animals shows that triclosan can cause decreases in thyroxine concentrations. However, the potential effects of triclosan on thyroid function in humans are unclear. Objective: To estimate the association between urinary triclosan concentrations and serum thyroid function biomarkers in women seeking assisted reproduction treatment in the Environment and Reproductive Health (EARTH) Study. Methods: We conducted a cross-sectional study of 317 women enrolled in the EARTH Study, a prospective preconception cohort that recruits Boston area couples. Using samples collected at study entry, we quantified urinary triclosan and serum thyroid function biomarker concentrations, specifically free and total thyroxine and triiodothyronine, thyroid-stimulating hormone (TSH), and thyroid antibodies. We estimated covariate-adjusted differences in thyroid function biomarkers per 10-fold increase in triclosan using linear regression models. We examined effect modification by body mass index (BMI) and infertility diagnosis. Results: The median urinary triclosan concentration was 7.8 μg/L (IQR: 3.0{\textendash}59 μg/L). Each 10-fold increase in triclosan was inversely associated with free triidothyronine (T3) (β: −0.06 pg/mL; 95\% CI: −0.1, −0.01), thyroperoxidase antibody (TPOAb) (−10\%; 95\% CI: −19, −0.4), and thyroglobulin antibody (TgAb) (−12\%; 95\% CI: −23,0.9) concentrations. BMI and infertility diagnosis modified the association of triclosan with free T3 and TPOAb, respectively. Conclusion: Urinary triclosan concentrations were inversely associated with specific serum thyroid function biomarkers in this cohort, suggesting that triclosan may affect thyroid homeostasis and autoimmunity.",

author = "Julianne Skarha and Lidia M{\'i}nguez-Alarc{\'o}n and Williams, \{Paige L.\} and Korevaar, \{Tim I.M.\} and \{de Poortere\}, \{Ralph A.\} and Broeren, \{Maarten A.C.\} and Ford, \{Jennifer B.\} and Melissa Eliot and Russ Hauser and Braun, \{Joseph M.\}",

note = "Funding Information: This work was supported by grants from the National Institute of Environmental Health Sciences ( R01 ES024381 and R01 ES027408 ). Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2019",

month = jan,

doi = "10.1016/j.envint.2018.11.015",

language = "English",

volume = "122",

pages = "256--262",

journal = "Environment international",

issn = "0160-4120",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women

AU - Skarha, Julianne

AU - Mínguez-Alarcón, Lidia

AU - Williams, Paige L.

AU - Korevaar, Tim I.M.

AU - de Poortere, Ralph A.

AU - Broeren, Maarten A.C.

AU - Ford, Jennifer B.

AU - Eliot, Melissa

AU - Hauser, Russ

AU - Braun, Joseph M.

PY - 2019/1

Y1 - 2019/1

N2 - Introduction: Exposure to the antimicrobial agent triclosan is ubiquitous. Research in animals shows that triclosan can cause decreases in thyroxine concentrations. However, the potential effects of triclosan on thyroid function in humans are unclear. Objective: To estimate the association between urinary triclosan concentrations and serum thyroid function biomarkers in women seeking assisted reproduction treatment in the Environment and Reproductive Health (EARTH) Study. Methods: We conducted a cross-sectional study of 317 women enrolled in the EARTH Study, a prospective preconception cohort that recruits Boston area couples. Using samples collected at study entry, we quantified urinary triclosan and serum thyroid function biomarker concentrations, specifically free and total thyroxine and triiodothyronine, thyroid-stimulating hormone (TSH), and thyroid antibodies. We estimated covariate-adjusted differences in thyroid function biomarkers per 10-fold increase in triclosan using linear regression models. We examined effect modification by body mass index (BMI) and infertility diagnosis. Results: The median urinary triclosan concentration was 7.8 μg/L (IQR: 3.0–59 μg/L). Each 10-fold increase in triclosan was inversely associated with free triidothyronine (T3) (β: −0.06 pg/mL; 95% CI: −0.1, −0.01), thyroperoxidase antibody (TPOAb) (−10%; 95% CI: −19, −0.4), and thyroglobulin antibody (TgAb) (−12%; 95% CI: −23,0.9) concentrations. BMI and infertility diagnosis modified the association of triclosan with free T3 and TPOAb, respectively. Conclusion: Urinary triclosan concentrations were inversely associated with specific serum thyroid function biomarkers in this cohort, suggesting that triclosan may affect thyroid homeostasis and autoimmunity.

AB - Introduction: Exposure to the antimicrobial agent triclosan is ubiquitous. Research in animals shows that triclosan can cause decreases in thyroxine concentrations. However, the potential effects of triclosan on thyroid function in humans are unclear. Objective: To estimate the association between urinary triclosan concentrations and serum thyroid function biomarkers in women seeking assisted reproduction treatment in the Environment and Reproductive Health (EARTH) Study. Methods: We conducted a cross-sectional study of 317 women enrolled in the EARTH Study, a prospective preconception cohort that recruits Boston area couples. Using samples collected at study entry, we quantified urinary triclosan and serum thyroid function biomarker concentrations, specifically free and total thyroxine and triiodothyronine, thyroid-stimulating hormone (TSH), and thyroid antibodies. We estimated covariate-adjusted differences in thyroid function biomarkers per 10-fold increase in triclosan using linear regression models. We examined effect modification by body mass index (BMI) and infertility diagnosis. Results: The median urinary triclosan concentration was 7.8 μg/L (IQR: 3.0–59 μg/L). Each 10-fold increase in triclosan was inversely associated with free triidothyronine (T3) (β: −0.06 pg/mL; 95% CI: −0.1, −0.01), thyroperoxidase antibody (TPOAb) (−10%; 95% CI: −19, −0.4), and thyroglobulin antibody (TgAb) (−12%; 95% CI: −23,0.9) concentrations. BMI and infertility diagnosis modified the association of triclosan with free T3 and TPOAb, respectively. Conclusion: Urinary triclosan concentrations were inversely associated with specific serum thyroid function biomarkers in this cohort, suggesting that triclosan may affect thyroid homeostasis and autoimmunity.

UR - https://www.scopus.com/pages/publications/85056998669

U2 - 10.1016/j.envint.2018.11.015

DO - 10.1016/j.envint.2018.11.015

M3 - Article

C2 - 30477815

AN - SCOPUS:85056998669

SN - 0160-4120

VL - 122

SP - 256

EP - 262

JO - Environment international

JF - Environment international

ER -

Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women

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