Curdlan-mediated regulation of human phagocyte-specific chitotriosidase

M (Marco) van Eijk, T Voorn-Brouwer, SS Scheij, Adrie Verhoeven, RG Boot, JMFG Aerts

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Abstract

Human phagocyte-specific chitotriosidase is part of innate immunity and shows anti-fungal activity towards chitin-containing fungi. We investigated the effect of stimulation of the C-type lectin receptor dectin-1 by beta-1,3-glucan (curdlan) on chitotriosidase expression and release by human phagocytes. We observed that curdlan triggers chitotriosidase release from human neutrophils. In addition, we show that curdlan impairs chitotriosidase induction in monocytes. Finally, curdlan temporarily induces chitotriosidase in enzyme-expressing monocyte-derived macrophages, followed by reduction of chitotriosidase expression after prolonged stimulation. These data on regulation of phagocyte-specific chitotriosidase following curdlan recognition support an important role of chitotriosidase in the elimination of chitin-containing pathogens. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)3165-3169
Number of pages5
JournalFEBS Letters. Journal for the Rapid Publication of Short Reports in Biochemistry .....
Volume584
Issue number14
Publication statusPublished - 2010

Research programs

  • EMC COEUR-09

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