Abstract
Stroke rate after transcatheter aortic valve replacement (TAVR) is currently approximately 2-3%, and strokes have a tremendous impact on patients' quality of life. Embolic protection devices may possibly reduce the number of strokes, but randomized data proving that is currently lacking. Histopathological studies with filter-based devices demonstrate capture of embolized debris in almost all patients, which may suggest that these devices may stop embolized particles from reaching the brain. Imaging studies show brain injury in the vast majority after TAVR as well; however, not all of them lead to clinical symptoms. The impact of these silent lesions is not fully understood but is thought not to be trivial as these lesions are linked to early neurocognitive decline. This chapter will discuss the mechanism and clinical impact of stroke after TAVR, current available embolic protection devices, histopathological characteristics of captured debris, and available evidence of neuroprotection in TAVR.
Original language | English |
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Title of host publication | Mastering Structural Heart Disease |
Publisher | John Wiley & Sons Inc. |
Chapter | 21 |
Pages | 163-168 |
Number of pages | 6 |
ISBN (Electronic) | 9781119807841 |
ISBN (Print) | 9781119807827 |
DOIs | |
Publication status | Published - 27 Mar 2023 |
Bibliographical note
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